Kyushu University · 의학
Goro Motomura 교수의 연구실은 대퇴부 골수막증(osteonecrosis of the femoral head, ONFH)의 병태생리학적 메커니즘과 치료 전략을 규명하는 데 초점을 맞추고 있습니다. 특히 스테로이드 유도성 골수막증 예방을 위한 약물 조합의 효과, 병변의 구조적 붕괴 메커니즘, 그리고 초기 단계에서의 스트레스 분포 특성에 대한 유저스펙터 피니트 엘리먼트 모델링(FEM)을 활용한 생체역학적 분석을 수행하고 있습니다. 고해상도 영상(마그네틱 리소낸싱, CT, 미세CT)과 임상 데이터를 융합한 정밀한 분석이 핵심입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
This study experimentally confirmed that the combined use of an anticoagulant and a lipid-lowering agent helps prevent steroid-induced ON in rabbits.
In order to investigate the mechanisms of collapse in osteonecrosis of the femoral head, we examined which part of the femoral head was the key point of a collapse and whether a collapsed region was associated with the size of the necrotic lesion. Using 30 consecutive surgically removed femoral heads we retrospectively analysed whole serial cut sections, specimen photographs, specimen radiographs and histological sections. In all of the femoral heads, collapse consistently involved a fracture at
Stress distribution remains unclear in early-stage osteonecrosis of the femoral head (ONFH). To clarify this issue, we generated patient-specific finite element models (FEMs) from 51 patients with ONFH. Patients' hips were classified into three groups: ONFH without a sclerotic boundary (Stage 1, n = 6), ONFH with a sclerotic boundary (Stage 2, n = 10), and ONFH with both a sclerotic boundary and <2 mm collapse (Stage 3, n = 35). Four hips without ONFH were used as controls. Stress distribution i
