Han Suk Ryu
서울대학교 의과대학 병리학과 · 의학
한숙류 교수의 연구실은 주로 갑상선암, 간세포질환 및 피부암과 같은 암의 조기 진단 및 치료 전략 개발에 초점을 맞추고 있습니다. 특히, NAD⁺ 대사 경로와 SIRT1/PARP1 조절을 통한 암 예방 및 치료 메커니즘, 암 미세환경 내 면역조절 세포의 역할을 중심으로 기초 및 임상 연계 연구를 수행하고 있습니다. 또한, 면역조직화학적 마커를 활용한 암 종별 구별 및 보조 진단 기법 개발에도 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Nicotinamide (NAM) is a water-soluble form of Vitamin B3 (niacin) and a precursor of nicotinamide-adenine dinucleotide (NAD<sup>+</sup>) which regulates cellular energy metabolism. Except for its role in the production of adenosine triphosphate (ATP), NAD<sup>+</sup> acts as a substrate for several enzymes including sirtuin 1 (SIRT1) and poly ADP-ribose polymerase 1 (PARP1). Notably, NAM is an inhibitor of both SIRT1 and PARP1. Accumulating evidence suggests that NAM plays a role in cancer preve
Aims and background Differential diagnosis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma is sometimes difficult to accurately perform. Methods Eight markers including cytokeratin 7 (CK7), cytokeratin 19 (CK19), MOC31, CD10, glypican 3 (GPC3), claudin 4, biglycan and high mobility group A1 (HMGA1) were immunohistochemically stained in samples from 179 surgically resected hepatocellular carcinomas and 127 intrahepatic cholangiocarcinomas, and the rates of marker expression were s
Although the reviewer should be aware of distinctive cytomorphological alterations, the SP technique is reliable for the evaluation of breast lesions with the advantage of easy interpretation and a diagnostic accuracy equivalent to CS.
IDO expression and infiltration of FOXP3+ Treg cells were closely related to each other and were associated with aggressive features of PTMC, suggesting that disruption of antitumor immunity by IDO expression, and thus, infiltration of FOXP3+ Treg cells may contribute to tumor progression in PTMC.
Our findings indicate that CXCL12 might serve as an effective novel supplementary diagnostic marker for PTC.
