Hee-Sun Kim
이화여자대학교 생화학과 · 생화학·유전·분자생물학
Hee-Sun Kim 교수의 연구실은 신경염증, 뇌질환 및 신경퇴행성질환의 분자 기전을 규명하고, 천연물 유래 화합물이 신경세포 보호 및 염증 조절에 미치는 영향을 중심으로 연구를 진행하고 있습니다. 특히 마이크로글리아의 과활성화와 난류성 세포사(necroptosis)가 관련된 신경염증 반응을 조절하는 타겟을 탐색하고 있으며, 성분이 밝혀진 천연물소재(예: 콤파운드 K, Rg5, 락노카르핀 등)의 신경보호 작용 메커니즘을 분석하고 있습니다. 이와 함께 운동이 뇌의 신경가소성과 신경재생에 미치는 영향을 실험적으로 규명하고 있어, 신경퇴행성질환 치료 전략 개발에 기여하고자 합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Aberrant expression of matrix metalloproteinase-9 (MMP-9) is implicated in the process of invasion and angiogenesis of malignant tumors as well as in inflammatory diseases of the CNS. Therefore, the development of compounds that can inhibit or suppress MMP-9 is required to treat brain tumors. We investigated the effects of a ginseng saponin metabolite, compound K (20-O-(beta-D-glucopyranosyl)-20(S)-protopanaxadiol), on MMP-9 expression in human astroglioma cells. Compound K significantly inhibit
Microglia are resident immune cells in the central nervous system. They play a role in normal brain development and neuronal recovery. However, overactivation of microglia causes neuronal death, which is associated with neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. Therefore, controlling microglial activation has been suggested as an important target for treatment of neurodegenerative diseases. In the present study, we investigated the anti-inflammatory effect
Lonchocarpine is a phenylpropanoid compound isolated from <i>Abrus precatorius</i> that has anti-bacterial, anti-inflammatory, antiproliferative, and antiepileptic activities. In the present study, we investigated the antioxidant effects of lonchocarpine in brain glial cells and analyzed its molecular mechanisms. We found that lonchocarpine suppressed reactive oxygen species (ROS) production and cell death in hydrogen peroxide-treated primary astrocytes. In addition, lonchocarpine increased the
