Kyoto University · 생화학·유전·분자생물학
히데아키 카케야 교수의 연구실은 주로 천연물 화학과 약리학을 기반으로 한 신약 개발을 중심으로 활동하고 있습니다. 특히 항암제, 면역조절제, 신경성장 유도 물질 등 생물학적 활성을 가진 자연산물의 분리, 구조 규명 및 작용 기작 해명에 중점을 두고 있습니다. 다양한 곰팡이 및 미생물에서 유래한 신규 대사산물의 생합성과 생리활성을 규명하며, 암, 염증, 신경퇴행성 질환 등에 대한 치료제 개발을 추구하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTCytoxazone: A Novel Cytokine Modulator Containing a 2-Oxazolidinone Ring Produced by Streptomyces sp.Hideaki Kakeya, Masayuki Morishita, Hiroyuki Koshino, Tetsu-ichiro Morita, Kimiko Kobayashi, and Hiroyuki OsadaView Author Information The Institute of Physical and Chemical Research (RIKEN), Hirosawa 2-1, Wako-shi, Saitama 351-0198, Japan Cite this: J. Org. Chem. 1999, 64, 3, 1052–1053Publication Date (Web):January 5, 1999Publication History Received22 Se
Zearalenones are mycotoxins with estrogenic activity consisting of a resorcinol moiety fused to a 14-membered macrocyclic lactone and are produced by various Fusarium species. We found that Clonostachys rosea IFO 7063 was effectively capable of converting zearalenone (1) to cleavage product (2), 1-(3,5-dihydroxyphenyl)-10'-hydroxy-1'E-undecene-6'-one. Moreover, cleavage product 2 did not show potent estrogenic activity like that of 1 and 17beta-estradiol in the human breast cancer MCF-7 cell pro
Upon stimulation with antigen, naive CD4+ cells can differentiate into distinct subsets defined by their cytokine secretion pattern.Human allergen-specific Th cells generally belong to the Th2 phenotype and produce IL-4,
A unique pentaketide dimer structure of a novel fungal metabolite with antiangiogenic activity, designated as epoxyquinol A (1), was determined on the basis of NMR spectral data as well as the X-ray crystallographic analysis. 1 inhibits the endothelial migration induced by vascular endothelial growth factor (ED100 = 3 mug/mL).
ADVERTISEMENT RETURN TO ISSUELetterNEXTNeuritogenic Effect of Epolactaene Derivatives on Human Neuroblastoma Cells Which Lack High-Affinity Nerve Growth Factor ReceptorsHideaki Kakeya, Chizuko Onozawa, Masakazu Sato, Koshi Arai, and Hiroyuki OsadaView Author Information Antibiotics Laboratory, The Institute of Physical and Chemical Research (RIKEN), Hirosawa 2-1, Wako-shi, Saitama 351-01, Japan, and Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., Yoshino-cho 1-403, Ohmiya-shi,
A novel anticancer drug, cytotrienin A, isolated from Streptomyces sp., induces apoptosis (or programmed cell death) in human promyelocytic leukemia HL-60 cells within 4 h. To elucidate the mechanism of this process, we performed an in-gel kinase assay using myelin basic protein (MBP) as a substrate and found the activation of kinase with an apparent molecular mass of 36 kDa (p36 MBP kinase). The dose of cytotrienin A required to activate p36 MBP kinase was consistent with that required to induc
This highlight focuses on our recent discoveries and chemical genetics approaches for bioactive microbial metabolites that target cancer cells, the cancer microenvironment, and cell membrane signalling. In addition, the development of two new platforms to identify the cellular targets of these molecules is also discussed.
A series of lipidic spirohemiaminals, designated streptoaminals, is reported. These were discovered by surveying the unique molecular signatures identified in the mass spectrometry data of the combined-culture broth of Streptomyces nigrescens HEK616 and Tsukamurella pulmonis TP-B0596. Mass spectrometry analysis showed that streptoaminals appeared as a cluster of ion peaks, which were separated by 14 mass unit intervals, implying the presence of alkyl chains of different lengths. The chemical str
