The University of Osaka · 신경과학
Hideo Matsuzaki 교수의 연구실은 신경세포의 생존과 기능 유지 메커니즘을 규명하는 데 초점을 맞추고 있습니다. 특히 VEGF와 IGF-1과 같은 성장인자가 신경세포에 미치는 신호전달 경로(PI3K/Akt 및 MEK/ERK 경로)를 통해 뇌세포를 보호하는 작용을 연구하고 있으며, 이는 신경퇴행성 질환 및 자폐 스펙트럼 장애의 병태생리 기전 규명에 기여하고자 합니다. 또한 신경세포의 손상에 대한 보호 작용과 관련된 분자 기전을 기초적으로 밝히는 데 주력하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
ABSTRACT Vascular endothelial growth factor (VEGF) is known as a selective endothelial cell mitogen that promotes angiogenesis and increases blood vessel formation in vivo. Here we report that VEGF has protective effects on primary hippocampal neurons against glutamate toxicity by acting on phosphatidylinositol 3‐kinase (PI3‐K)/Akt pathways and mitogen‐activated protein kinase kinase (MEK)/extracellular signal‐regulated kinase (ERK) pathways, operating independently of one another. Decrease in t
Emerging data indicate that growth factors such as insulin-like growth factor-1 (IGF-1) prevent neuronal death due to nitric oxide (NO) toxicity. On the other hand, growth factors can promote cell survival by acting on phosphatidylinositol 3-kinase (PI3-kinase) and its downstream target, serine-threonine kinase Akt, in various types of cells. Here, we examined the mechanism by which IGF-1 inhibits neuronal apoptosis induced by NO in primary hippocampal neurons. IGF-1 was capable of preventing ap
Individuals with autism spectrum disorders (ASD) tend to make inadequate social judgments, particularly when the nonverbal and verbal emotional expressions of other people are incongruent. Although previous behavioral studies have suggested that ASD individuals have difficulty in using nonverbal cues when presented with incongruent verbal-nonverbal information, the neural mechanisms underlying this symptom of ASD remain unclear. In the present functional magnetic resonance imaging study, we comp
This study was supported mainly by MEXT, Japan.
