Keio University · 의학
히로후무 카와쿠보 교수의 연구실은 식도암의 분자 기전과 치료 전략에 중점을 두고 있으며, 특히 전이성 림프절 역학과 수술적 치료 방식의 최적화를 연구하고 있습니다. 고도의 정밀 수술 기법인 3필드 림프절 단절과 미세외과적 식도절제술의 임상적 유효성 및 생존율 향상 효과를 분석하고 있습니다. 또한, 식도 내시경 생검을 통한 분자표지자 분석을 통해 '현장 암화' 개념을 검증하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Extended TMIE including thoracic duct resection increased the number of lymph nodes retrieved and was associated with improved survival in patients with cT1 N0 oesophageal squamous cell carcinoma.
Many molecular alterations occur in esophageal carcinogenesis; however, little is known about the molecular genetic events responsible for the development of carcinoma. We investigated the expression of ki67, p53, cyclin D1 and pRB in 105 biopsy specimens using immunohistochemistry from iodine unstained lesions as indicators of carcinogenesis of the esophagus. Also, the genetic alternation of esophageal dysplasia from patients with accompanying esophageal squamous cell carcinoma (ESCC) was exami
Esophageal cancer has one of the highest malignant potentials of any type of tumor. The 3-field lymph node dissection is the standard procedure in Japan for surgically curable esophageal cancer in the middle or upper thoracic esophagus. Minimally invasive esophagectomy is being increasingly performed in many countries, and several studies report its feasibility and curability; further, the magnifying effect of the thoracoscope is another distinct advantage. However, few studies have reported tha
