Nagoya University · 의학
Hirohisa Watanabe 교수의 연구실은 신경퇴행성질환, 특히 다발성 위축증(MSA), 루이체병변성질환(DLB), 파킨슨병 등에서의 뇌와 심장의 신경조직 손상 메커니즘을 핵심으로 연구하고 있습니다. 특히 MSA의 조기 진단을 위한 1H-MRS와 심장 심부전성 신경 손상 평가를 위한 123I-MIBG 심장 스캔을 통해 병리학적 기전을 규명하고 있으며, 신경생물학적 기초 연구와 임상 응용을 융합한 연구를 진행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
We investigated the disease progression and survival in 230 Japanese patients with multiple system atrophy (MSA; 131 men, 99 women; 208 probable MSA, 22 definite; mean age at onset, 55.4 years). Cerebellar dysfunction (multiple system atrophy-cerebellar; MSA-C) predominated in 155 patients, and parkinsonism (multiple system atrophy-parkinsonian; MSA-P) in 75. The median time from initial symptom to combined motor and autonomic dysfunction was 2 years (range 1-10). Median intervals from onset to
Cardiac (123)I-meta-iodobenzylguanidine (MIBG) uptake was measured in 11 patients with dementia with Lewy bodies (DLB), 10 patients with Alzheimer's disease (AD), and 10 age matched control subjects. The severity of cognitive impairment and duration of symptoms in patients with DLB matched that in the patients with AD. The heart/mediastinum (H/M) ratio of MIBG uptake in the patients with AD was indistinguishable from that in the control subjects. However, the H/M ratio in all patients with DLB w
(1)H-MRS showed widespread neuronal and axonal involvement in MSA. The NAA/Cr reduction in the pontine base proved highly informative in the early diagnosis of MSA prior to MRI changes and even before any clinical manifestation of symptoms.
VH in PD can occur due to distinctive neuroanatomical involvement.
