名古屋大学 · Medicine
히로코 츠쿠마라 교수의 연구실은 신경내분비학적 메커니즘을 중심으로 생식 호르몬 분비 조절, 특히 뇌하우머의 MCH, 코르티코트로핀 릴리진 호르몬(CRH), 도파민계 신경세포 및 킵세프틴 신경세포의 역할을 다룹니다. 주로 뇌의 특정 영역(예: 뇌간, 부싘이식핵)에서 분비되는 신호 분자가 레티누이린 호르몬(LH) 분비의 파ulses와 생식주기 조절에 미치는 영향을 실험적으로 규명하고 있으며, 동물 모델(대am, 원숭이 등)을 통해 인간 생식 기능의 기초 메커니즘을 밝혀내는 데 초점을 맞추고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Melanin-concentrating hormone (MCH) has been reported to be involved in the regulation of feeding behaviour in rats and mice. Because many neuropeptides that influence ingestive behaviour also regulate reproductive function, the present study was designed to determine if central administration of MCH changes pulsatile secretion of luteinizing hormone (LH) in the rats. Wistar-Imamichi strain female rats were ovariectomized and implanted with oestradiol to produce a moderate inhibitory feedback ef
The oestrogen-induced luteinising hormone (LH) surge is evident in male primates, including humans, whereas male rodents never show the LH surge, even when treated with a preovulatory level of oestrogen. This suggests that the central mechanism governing reproductive hormones in primates is different from that in rodents. The present study aimed to investigate whether male Japanese monkeys conserve a brain mechanism mediating the oestrogen-induced LH surge via activation of kisspeptin neurones.
The present study examined which subtype of adrenergic receptor in the paraventricular nucleus (PVN) has a role in regulating pulsatile LH secretion and whether CRH mediates the effect of norepinephrine (NE) injection into the PVN on pulsatile LH secretion in ovariectomized (OVX) and ovariectomized estradiol (E2)-treated (OVX + E2) rats. All animals were OVX, and some were sc implanted with Silastic capsules containing E2 dissolved in peanut oil. One week after ovariectomy and E2 implantation, g
Effects of the suckling stimulus on the daily LH surge induced by chronic oestrogen treatment were examined in ovariectomized lactating rats. Wistar-Imamichi strain rats were kept under 14 h light:10 h darkness (lights on at 05.00 h). Litter size was adjusted to eight on day 1 (day 0 = day of parturition) and ovariectomy performed on day 2. Lactating rats deprived of their litters on day 0 served as nonlactating controls. Silicone elastomer tubing filled with oestradiol was implanted on day 6 or
