Hokkaido University · 의학
히로시 키다 교수의 연구실은 인플루엔자 바이러스의 자연적 저장소이자 전파 매개체로 작용하는 조류와 돼지의 역할을 중심으로 한 유전자 재조합 및 병원성 메커니즘을 연구하고 있습니다. 특히 조류에서 유래한 인플루엔자 바이러스가 돼지 등 숙주에서 어떻게 전파되고 변이를 겪는지를 실험적으로 규명하며, 바이러스의 숙주 범위 확장과 유행 가능성에 대한 기초 자료를 제공하고 있습니다. 이 연구들은 인플루엔자 유행병 예방에 핵심적인 과학적 근거를 마련하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Pandemic strains of influenza A virus arise by genetic reassortment between avian and human viruses. Pigs have been suggested to generate such reassortants as intermediate hosts. In order for pigs to serve as 'mixing vessels' in genetic reassortment events, they must be susceptible to both human and avian influenza viruses. The ability of avian influenza viruses to replicate in pigs, however, has not been examined comprehensively. In this study, we assessed the growth potential of 42 strains of
Influenza viruses A/duck/Hokkaido/5/77 (Hav7N2), A/budgerigar/Hokkaido/1/77 (Hav4Nav1), A/Kumamoto/22/76 (H3N2), A/Aichi/2/68 (H3N2), and A/New Jersey/8/76 (Hsw1N1) were experimentally inoculated into Pekin ducks. Of these, the influenza viruses of duck and budgerigar origin replicated in the intestinal tract of the ducks. The infected ducks shed the virus in the feces to high titers, but did not show clinical signs of disease and scarcely produced detectable serum antibodies. Using immunofluore
Three influenza A viruses possessing hemagglutinin-Hav7 and neuraminidase-N2 were isolated from 20 wild free-flying ducks in Hokkaido, Japan in autumn, 1977. The neuraminidase antigen of these viruses cross-reacted with the Asian influenza virus (H2 N2) but reacted scarcely with the Hong Kong strain (H3 N2Y in cross neuraminidase-inhibition tests.
