Nagoya University · 의학
Hiroshi Kiyama 교수의 연구실은 중추신경계의 신경질환 메커니즘을 밝히는 데 초점을 맞추고 있으며, 특히 미세아교세포의 활성화 및 기능 전환 메커니즘, 신경염증 반응 조절, 그리고 신경망의 유지·재편성 과정에서의 세포 울타리 기능을 중심으로 연구를 진행하고 있습니다. 특히 미세아교세포의 수용체 기반 활성화, 신경세포와의 상호작용, 그리고 신경병성 통증에서의 역할에 대한 전기현미경 기반 분석을 통해 기초 신경과학의 핵심 문제를 해결하고자 합니다. 또한, 뇌의 면역 반응과 신경망의 가소성 유지를 위한 세포 간 상호작용 메커니즘을 다각도로 탐구하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Microglia are activated after neuronal injury and in neurodegenerative diseases, and trigger neuroinflammation in the central nervous system (CNS). Microglia-derived neuroinflammation has both beneficial and detrimental effects on neurons. Because the timing and magnitude of microglial activation is thought to be a critical determinant of neuronal fate, understanding the molecular mechanisms underlying microglial activation is required to enable establishment of microglia-targeted therapies for
Several types of myeloid cell are resident in the CNS. In the steady state, microglia are present in the CNS parenchyma, whereas macrophages reside in boundary regions of the CNS, such as perivascular spaces, the meninges and choroid plexus. In addition, monocytes infiltrate into the CNS parenchyma from circulation upon blood-brain barrier breakdown after CNS injury and inflammation. Although several markers, such as CD11b and ionized calcium-binding adapter molecule 1 (Iba1), are frequently use
A novel enzyme-labelled oligonucleotide probe specific for oxytocin messenger ribonucleic acid (mRNA) and a radiolabelled oligonucleotide probe specific for vasopressin mRNA were used together to visualize both oxytocin and vasopressin mRNA's in hypothalamus sections from salt loaded (2% saline) rats. The results demonstrate that the majority of magnocellular neurons contain only oxytocin or vasopressin mRNA, however a small number of neurons, 1% to 2%, contained both oxytocin and vasopressin tr
Elimination of dead or live cells take place in both a healthy and diseased central nervous system (CNS). Dying or dead cells are quickly cleared by phagocytosis for the maintenance of a healthy CNS or for recovery after injury. Live cells or parts thereof, such as the synapses and myelin, are appropriately eliminated by phagocytosis to maintain or refine neural networks during development and adulthood. Microglia, the specific population of resident macrophages in the CNS, are classically consi
The mechanisms underlying neuropathic pain are poorly understood. However, several studies have implied a role for reactive microglia located in the dorsal horn in neuropathic pain. To clarify the roles of activated microglia in neuropathic pain, we investigated the interactions among microglia and other neural components in the dorsal horn using electron microscopy. Microglia were more abundantly localized in layers II-III of the dorsal horn than in other areas, and some of them adhered to and
