The University of Tokyo · 의학
Hiroshi Kobayashi 교수의 연구실은 소견세포학적 및 분자생물학적 접근을 통해 희귀 종양, 특히 소견세포성 퇄종(soft tissue sarcoma)과 악성 주변신경鞘종양(MPNST)의 진단 및 치료 전략을 모색하고 있습니다. ROS 측정의 정밀도 향상을 위한 분석 방법론 개선과 함께, 신약(예: 트라베세틴, 에리불린)의 임상적 효과 평가에도 주력하고 있습니다. 특히 악성 궤양성 병변, 전이성 병소, 예후 인자 분석을 통한 개인화된 치료 접근이 핵심 연구 방향입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
A total of 28 donor semen samples were used to evaluate the characteristics of laboratory variability in measuring reactive oxygen species (ROS). The objectives of this study were to assess the interassay (same sample observed on different days by the same observers) variability; interdonor, intraobserver (replications of the same sample on the same day) variability; and interobserver (multiple observers on the same day with the same sample) variability of the luminol-dependent chemiluminescence
Initial trabectedin at 1.2 mg/m<sup>2</sup> has clinically meaningful benefits for patients with L-sarcoma and certain histological subtypes of TRS.
Navigation-assisted surgery using a 3D fluoroscopy-based navigation system is effective for tumors in patients with TIO.
Malignant fungating wounds in soft tissue sarcoma were significantly associated with a poor prognosis; however, the incidence of surgical complications and local recurrence after limb-salvage surgery was comparable to that of general soft tissue sarcoma cases. Limb-salvage surgery should be considered, if possible, to preserve the patient's quality of life because of the dismal prognosis of patients with malignant fungating wound in soft tissue sarcoma.
The prognostic factors in patients with metastatic soft tissue sarcoma at diagnosis are generally similar to those in patients with localized disease. The overall survival in patients differed significantly according to histologic subtype. Surgical resection of primary lesions, especially those with a wide margin, may be an independent prognostic factor. Further studies are needed identify which subgroup of patients would benefit the most from primary lesion surgery.
Neurotropic tropomyosin receptor kinase (NTRK) gene rearrangements have been reported in limited cases of sarcomas; however, to date, there has been only one report of such rearrangements in malignant peripheral nerve sheath tumors (MPNSTs). Herein, we describe a 51-year-old male patient with a buttock tumor arising from the sciatic nerve, which was diagnosed as MPNST with positive S-100 staining, negative SOX10 staining, and loss of trimethylation at lysine 27 of histone H3 (H3K27me3) confirmed
