Keio University · 의학
히로유키 야즈 교수의 연구실은 주로 각막 질환, 특히 투명성 손상과 관련된 염증 반응 및 혈관성 마커의 역할을 중심으로 연구를 진행하고 있습니다. 특히 DSAEK 수술 후 각막 내피 세포 밀도 감소와 관련된 사이토카인(IL-17A, MCP-1 등)과 혈관성 마커의 기전을 규명하고 있으며, 시력 저하와 관련된 후방 각막 위상 이상(POST)의 영향도 분석하고 있습니다. 또한, 진단 기술 혁신을 위해 스마트폰 연동형 휴대용 슬릿 램프 장치(Smart Eye Camera) 개발을 통해 원격 및 현장 진료의 가능성을 모색하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Higher preoperative levels of IL-17A, MCP-1, IFN-γ, E-selectin, and sICAM-1 in the AqH were associated with lower ECD after DSAEK for bullous keratopathy.
<i>Background:</i> Visual impairments and age-related eye diseases need to be detected and treated in a timely manner. However, this is often hampered by lack of appropriate medical equipment. We have invented a portable, recordable, and smartphone-attachable slit-lamp device, called the Smart Eye Camera (SEC). The aim of this study was to compare evaluating nuclear cataract (NUC) between the SEC and the conventional, non-portable slit-lamp microscope. <i>Methods:</i> A total of 128 eyes of 64 J
University Hospital Medical Information Network (UMIN) 000034460.
The SEC is as reliable as the conventional non-portable slit-lamp microscope for assessing ACDs.
None of the authors has a financial or proprietary interest in any material or method mentioned.
Posterior corneal HOAs can have a negative influence on the visual acuity after endothelial keratoplasty.
Topical tacrolimus may effectively and immediately reduce clinical signs and symptoms of noninfectious, non-necrotizing anterior scleritis in cases unresponsive to a course of topical steroid.
The assessment of conjunctival pseudomembrane in ocular GVHD is important to determine the stage of the case and to assess systemic GVHD. Furthermore, prompt removal of the pseudomembrane after diagnosis is an appropriate management to reduce the symptoms of ocular GVHD. The combination of topical steroids and immunosuppressive agents is suggested to be an effective treatment in management of overlap syndrome.
The use of eyewash solutions in Japan, especially in patients with allergic conjunctivitis and contact lens wearers, has been increasing. Our aim was to investigate how the use of preservative-free eyewash solution in healthy eyes for one month affects corneal safety and ocular surface mucin. We analyzed 42 eyes of 21 individuals (17 males, four females; mean age: 36.1 ± 7.4 years) without ocular allergies, dry eyes, or other ocular diseases through a prospective study. Eyes were randomized to a
Conjunctival papillomas with higher positive staining for Ki67 and p53 seem to have a higher risk of recurrence even after complete surgical excision and necessitate careful follow-up.
<b>Purpose</b>: We assessed the production of chemokines by human conjunctival fibroblasts in response to inflammation and the effects of omega (ω)-3 fatty acids on chemokine expression.<b>Methods</b>: Primary cultures of human conjunctival fibroblasts were incubated with interleukin-4 (IL-4) and tumor necrosis factor-alpha (TNF-α). The expression of eotaxin-1 and RANTES in response to pretreatment with docosahexaenoic acid (DHA) was investigated. Moreover, western blotting was used to evaluate
<title>Abstract</title> BACKGROUND: To examine the efficacy of 0.1% tacrolimus eye drops in the treatment of noninfectious, non-necrotizing anterior scleritis. METHODS: This prospective, single-arm study included nine patients (4 males and 5 females; mean age = 59.4 years, standard deviation = 10.5) with anterior scleritis. All patients were first treated with steroids for 1 month and then switched to tacrolimus eye drops alone. We defined baseline as the initiation of steroid or tacrolimus eye
