Ho‐Keun Kwon
연세대학교 의과대학 · 의학
Ho-Keun Kwon 교수의 연구실은 면역조절을 핵심으로 하는 미생물 기반 치료 전략을 연구하고 있습니다. 특히 프로바이오틱스가 조절성 T세포(Tregs)를 활성화하고, 항염증 및 자가면역질환 예방에 기여하는 면역조절 메커니즘을 규명하고 있습니다. 또한 시나몬 추출물이 NF-κB 및 AP-1 경로를 억제하여 종양 성장에 영향을 주는 항암 작용을 하는 것으로 밝혀내며 자연물 기반 면역조절제 개발에도 기여하고 있습니다. 이들의 연구는 면역계 조절을 통한 만성질환 예방 및 치료에 기여할 잠재력을 지닌다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The beneficial effects of probiotics have been described in many diseases, but the mechanism by which they modulate the immune system is poorly understood. In this study, we identified a mixture of probiotics that up-regulates CD4(+)Foxp3(+) regulatory T cells (Tregs). Administration of the probiotics mixture induced both T-cell and B-cell hyporesponsiveness and down-regulated T helper (Th) 1, Th2, and Th17 cytokines without apoptosis induction. It also induced generation of CD4(+)Foxp3(+) Tregs
Our study suggests that anti-tumor effect of cinnamon extracts is directly linked with enhanced pro-apoptotic activity and inhibition of NFkappaB and AP1 activities and their target genes in vitro and in vivo mouse melanoma model. Hence, further elucidation of active components of cinnamon extract could lead to development of potent anti-tumor agent or complementary and alternative medicine for the treatment of diverse cancers.
The beneficial effects of probiotics have been described in many diseases, but the mechanism by which they modulate the immune system is poorly understood. In this study, we identified a mixture of probiotics that up-regulates CD4+Foxp3+ regulatory T cells (Tregs). Administration of the probiotics mixture induced both T-cell and B-cell hyporesponsiveness and down-regulated T helper (Th) 1, Th2, and Th17 cytokines without apoptosis induction. It also induced generation of CD4+Foxp3+ Tregs from th
Our study suggests the potential of cinnamon extract as an anti-inflammatory agent by targeting the generation of regulatory APCs and IL-10(+) regulatory T cells.
Probiotics, live microorganisms that confer health benefits when consumed in adequate amounts, have gained significant attention for their potential therapeutic applications. The beneficial effects of probiotics are believed to stem from their ability to enhance intestinal barrier function, inhibit pathogens, increase beneficial gut microbes, and modulate immune responses. However, clinical studies investigating the effectiveness of probiotics have yielded conflicting results, potentially due to
Significance The transcription factor FoxP3 defines and controls regulatory T cells (Tregs), themselves essential components of immunoregulatory pathways. From a highly granular scanning mutagenesis, the results of our study point to very integrated functions of the protein’s domains, quite different from predictions of simple modular models. The phenotype of mutant mice carrying subtle mutations in Foxp3, which deviate from the acute lymphoproliferation and autoimmunity linked to Treg deficienc
<i>ETS1</i> has shown dichotomous roles as an oncogene and a tumor suppressor gene in diverse cancers, but its functionality in breast cancer tumorigenesis still remains unclear. We utilized the Cancer Genome Atlas (TCGA) database to analyze comprehensive functions of <i>ETS1</i> in human breast cancer (BRCA) patients by investigating its expression patterns and methylation status in relation to clinical prognosis. <i>ETS1</i> expression was significantly diminished by hyper-methylation of the <
