Hoon‐Chul Kang
연세대학교 의예과 · 의학
강훈철 교수의 연구실은 주로 저카로우리드 다이어트(Ketogenic Diet, KD)를 활용한 내과적 치료법, 특히 약물에 내성인 어린이 간질 환자를 대상으로 한 비약리적 치료 전략에 중점을 두고 있습니다. 특히 저지방 다이어트의 특성과 장기적 안정성, 생장 지연 등의 부작용을 고려한 치료 기간 최적화와 보조 치료제의 영향 평가를 포함한 종합적 접근을 연구하고 있습니다. 또한, 수정 아티킨 다이어트(MAD)와 같은 변형 다이어트의 내약성과 임상적 효과에 대해서도 지속적으로 연구하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Most complications of the KD are transient and can be managed easily with various conservative treatments. However, life-threatening complications should be monitored closely during follow-up.
The KD was a safe and effective therapy for seizures in children with intractable epilepsy and RC complex defects.
The KD is a safe and effective alternative therapy for intractable childhood epilepsy in Korea, although the customary diet contains substantially less fat than traditional Western diets, but life-threatening complications should be monitored closely during follow-up.
The modified Atkins diet was well tolerated and sometimes a modified Atkins diet can be substituted for the conventional ketogenic diet. Serious complications were rare, but long-term complications remain to be determined.
The pattern of neuropsychometric changes with TPM seemed to be slightly worse overall than CBZ. However, outcome with the minimum target dose did not differ significantly in comparisons between the treatment groups.
Use of the KD for only 8 months in children who become spasm-free appears to be justified, with similar outcomes, recurrence rate, and less growth disturbance than a longer-term, traditional use.
