고려대학교 · 의학
Hye Jin Yoo 교수의 연구실은 대사증후군과 관련된 대사질환, 특히 당뇨병과 비알코올성 간지방증이 혈관질환에 미치는 영향을 중심으로 연구를 진행하고 있습니다. 간에서 분비되는 헤파토키나와 지방조직에서 분비되는 아디포카인 등 생체 활성 단백질이 동맥경화 및 혈관 stiffness의 발달에 미치는 영향을 규명하고 있으며, 이를 통해 새로운 생물학적 마커와 치료 타겟을 탐색하고 있습니다. 특히, 혈관 기능 이상과 대사 이상 간의 분자 기전을 밝히는 데 초점을 맞추고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Circulating omentin-1 level was independently correlated with arterial stiffness and carotid plaque in type 2 diabetes, even after adjusting for other cardiovascular risk factors and detailed medication history.
Non-alcoholic fatty liver disease, which is considered a hepatic manifestation of metabolic syndrome, independently increases the risks of developing cardiovascular disease (CVD) and type 2 diabetes mellitus. Recent emerging evidence suggests that a group of predominantly liver-derived proteins called hepatokines directly affect the progression of atherosclerosis by modulating endothelial dysfunction and infiltration of inflammatory cells into vessel walls. Here, we summarize the role of the rep
ClinicalTrials.gov NCT01668888.
Clinicaltrials.gov NCT01594710.
The traditional perception of adipose tissue as a storage organ of fatty acids has been replaced by the notion that adipose tissue is an active endocrine organ, releasing various adipokines that are involved in the pathogenesis of obesity-related metabolic disturbances. Obesity is a well-known risk factor for atherosclerosis, and accelerates atherosclerosis by many mechanisms such as increase in blood pressure and glucose level, abnormal lipid profiles, and systemic inflammation. Furthermore, gr
The circulating chemerin level was an independent risk factor for arterial stiffness even after adjusting for other cardiovascular risk factors.
Progranulin efficiently inhibited LPS-mediated pro-inflammatory signaling in endothelial cells through activation of the Akt/eNOS pathway and attenuation of the NF-κB pathway, suggesting its protective roles in vascular endothelium against inflammatory reaction underlying atherosclerosis.
The simple anthropometric parameters, such as waist circumference and waist-to-height ratio, are as useful as DXA and CT for predicting NAFLD in Korean adults.
