Hye Jung Park
연세대학교 의과대학 영상의학교실 · 의학
Hye Jung Park 교수의 연구실은 알레르기성 질환과 호흡기 질환의 유전적 소인 및 환경 요인의 상호작용을 중심으로 연구를 진행하고 있습니다. 특히 한국인의 HLA 유전자 빈도 분석을 통해 약물유발성 중증피부염(SJS/TEN)의 위험도를 평가하고, 알레르겐 민감도의 장기적 변화와 환경적 요인(예: 기후 변화, 꽃가루)의 영향을 분석하고 있습니다. 또한 나노소재의 생체 독성과 천식 모델에서의 영향에 대해서도 실험적 접근을 통해 안전성 평가를 수행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
HLA gene frequencies varied in Korea. Screening of HLA-B*58:01 before the use of allopurinol might be needed to anticipate probability of SJS/TEN.
In light of the above results, we revealed the changes in skin reactivity to inhalant allergens that have occurred in Korean allergic patients over the past three decades. Since outdoor environmental factors such as the amount of pollen, global warming and plant distribution causes the changes in skin reactivity, further study and continuous close observation will be needed.
Silica nanoparticles (SNPs) are widely used in many scientific and industrial fields despite the lack of proper evaluation of their potential toxicity. This study examined the effects of acute exposure to SNPs, either alone or in conjunction with ovalbumin (OVA), by studying the respiratory systems in exposed mouse models. Three types of SNPs were used: spherical SNPs (S-SNPs), mesoporous SNPs (M-SNPs), and PEGylated SNPs (P-SNPs). In the acute SNP exposure model performed, 6-week-old BALB/c fem
PRISm patients are likely to develop COPD, and should be monitored carefully, especially older patients and those with wheezing, regardless of lung function.
The most important inhalant allergens in Korea are house dust mites followed by cockroach, mugwort, oak, Japanese hop, and dog dander in indoor environment, in which The dominant species of house dust mites were different according to region.
