Hye Yun Park
성균관대학교 의과대학 · 의학
Hye Yun Park 교수의 연구실은 만성 폐질환, 특히 만성 폐쇄성 폐질환(COPD)과 관련된 질병 진행 메커니즘, 위험 인자, 합병증(예: 폐암)의 기전을 중심으로 연구를 진행하고 있습니다. 특히 혈중 CC-16 수치의 임상적 의미, 흡연과 폐질환 간의 관계, 폐생검에서의 기능적 손상, 그리고 폐결핵 이환력이 COPD 환자에서 폐암 발생에 미치는 영향을 다각도로 분석하고 있습니다. 또한 호흡기질환 환자의 사망 위험도와 장기적 예후에 영향을 미치는 요인들에 대해서도 정량적 연구를 수행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Serum CC-16 is associated with disease progression, and may assist in the identification of "rapid progressors." However, the absence of CC-16 does not appear to modify the risk of cigarette-related COPD in mice.
There has been limited evidence for the association between chronic obstructive pulmonary disease (COPD) and the incidence of lung cancer among never smokers. We aimed to estimate the risk of lung cancer incidence in never smokers with COPD, and to compare it with the risk associated with smoking. This cohort study involved 338 548 subjects, 40 to 84 years of age with no history of lung cancer at baseline, enrolled in the National Health Insurance Service National Sample Cohort. During 2 355 005
Repeated derecruitments exacerbated lung injury, particularly at the bronchiolar level in the dependent portion. Strategies to minimize this type of injury should be incorporated when designing optimal ventilator strategies in acute respiratory distress syndrome patients.
In this large national cohort, COPD patients were at a statistically significant higher risk for all-cause mortality than those without COPD. They were more likely to die from chronic lower airway disease, lung cancer and pneumonia than subjects without COPD. The impact of COPD on specific mortalities was stronger in younger subjects.
Abstract Introduction The use of low-dose steroid therapy in the management of septic shock has been extensively studied. However, the association between the timing of low-dose steroid therapy and the outcome has not been evaluated. Therefore, we evaluated whether early initiation of low-dose steroid therapy is associated with mortality in patients with septic shock. Methods We retrospectively analyzed the clinical data of 178 patients who received low-dose corticosteroid therapy for septic sho
<b>Rationale:</b> Although a history of pulmonary tuberculosis (PTB) is a risk factor for developing both chronic obstructive pulmonary disease (COPD) and lung cancer, it remains unclear whether a history of PTB affects lung cancer development in patients with COPD. <b>Objectives:</b> To investigate whether a history of PTB is associated with an increased risk of lung cancer development in a population with COPD. <b>Methods:</b> This cohort study included a nationwide representative sample of 13
In this large longitudinal cohort study, blood eosinophil counts were positively associated with the risk of developing of OLD. Our findings indicate a potential role of the eosinophil count as an independent risk factor for developing COPD.
High blood eosinophils and high plasma periostin were associated with improved lung function after 3-month ICS/LABA treatment. In particular, high blood eosinophils, in combination with age and baseline lung function parameters, might be a possible biomarker for identification of COPD patients with favorable FEV1 improvement in response to ICS/LABA treatment.
