김혜진 교수

The migration of vascular smooth muscle cells (VSMCs) into the intima, an important step in injury-induced neointimal hyperplasia, requires the activation of nuclear factor-kappaB (NF-kappaB) and the consequent up-regulation of matrix metalloproteinase-9 (MMP-9). This study was undertaken to test for a possible effect of alpha-lipoic acid (ALA), a potent inhibitor of NF-kappaB, on MMP-9 expression. ALA inhibited high-glucose- and TNF-alpha-stimulated VSMC migrations in vitro. It also inhibited h

One of the temperature-sensitive alleles of CEG1, a guanylyltransferase subunit of the Saccharomyces cerevisiae capping enzyme, showed 6-azauracil (6AU) sensitivity at the permissive growth temperature, which is a phenotype that is correlated with a transcription elongation defect. This temperature-sensitive allele, ceg1-63, has an impaired ability to induce PUR5 in response to 6AU treatment and diminished enzyme-GMP formation activity. However, this cellular and molecular defect is not primaril

CE and AE have different radiological characteristics, as shown by the right-left propensity and lesions patterns of cerebral infarcts.

A 4-year-old, neutered male Maltese presented with a 2-month history of right hemiparesis. The radiographic findings revealed bone lysis, and sclerotic changes in the right section of the fifth and sixth cervical bones with a mild radiolucent mass around the lesion. The magnetic resonance imaging revealed a hyperintense mass located in the region extending from the muscles to the bones and compressing the spinal cord. The mass was removed via a hemilaminectomy in the cervical area using the vent

Membrane proteins sense extracellular cues and transduce intracellular signaling to coordinate directionality and speed during cellular migration. They are often localized to specific regions, as with lipid rafts or tetraspanin-enriched microdomains; however, the dynamic interactions of tetraspanins with diverse receptors within tetraspanin-enriched microdomains on cellular surfaces remain largely unexplored. Here, we investigated effects of tetraspan(in) TM4SF5 (transmembrane 4 L6 family member

The leading cause of cancer-related death globally has been identified as lung cancer. Early lung nodule detection is critical for lung cancer therapy and patient survival. The Gard Cam++ Class Activation Function is used with a squeeze-and-excite network to provide a revolutionary method for differentiating malignant from benign lung nodules on CT scans. The new SENET (Squeeze-and-Excitation Networks) Grad Cam++ module, which combines the features calibration and discrimination benefits of SENE

We examined the effect of docosahexaenoic acid (DHA)-enriched structured lipids-diacylglycerol (SL-DG), which were synthesized using soybean oil (SO) and algae oil (AO), on hepatic lipid metabolism and the mRNA expression of genes involved in hepatic steatosis of C57BL/6J-Lep(ob/ob) compared to the SL-triacylglycerol (TG). The animals were fed a high-fat (10% lard and 10% test oils) and high-cholesterol (0.2% cholesterol) diet for 12 weeks. Mice fed SL-DG showed a lower total white adipose tissu

Echinococcosis occurs mainly in areas with heavy livestock farming, such as Central Asia, America, and Australia. Echinococcus granulosus sensu lato (s.l.) infection causes echinococcosis in intermediate hosts, such as sheep, cattle, goats, camels, and horses. Numerous cases of echinococcosis occur in Uzbekistan as stock farming is a primary industry. Epidemiological and genetic studies of E. granulosus s.l. are very important for mitigating its impact on public health and the economy; however,

The surface air temperature in the northern mid-latitudes during winter showed a significant cooling trend from the late 1990s to the early 2010s, in spite of increasing greenhouse gas concentrations. This unexpected cooling, which was particularly strong across Eurasia, has been partly attributed to Arctic sea-ice loss. Here, the statistical relationship between Arctic sea-ice loss and surface air-temperature change during winter in Eurasia, which is often referred to as the warm Arctic–cold Eu

The era of big data has led to the necessity of artificial intelligence models to effectively handle the vast amount of clinical data available. These data have become indispensable resources for machine learning. Among the artificial intelligence models, deep learning has gained prominence and is widely used for analyzing unstructured data. Despite the recent advancement in deep learning, traditional machine learning models still hold significant potential for enhancing healthcare efficiency, e

Poststroke hypotension may be related to early neurological deterioration and infarct progression by decrease of cerebral perfusion, particularly in patients with ischemic penumbra. However, optimal management guideline of blood pressure in the setting of acute stroke is absent, and remains a matter of debate. We report here a patient who had early neurological deterioration accompanied by systemic hypotension. Phenylephrine-induced hypertensive therapy by imaging-based decision making successfu

이 연구의 궁극적 목표는 한국어 학습자들이 한국인의 정서 혹은 정신문화의 한 요소인 흥을 이해하여 한국 문화에 대한 심층적인 이해를도모함은 물론 이를 바탕으로 상호 문화적 능력을 향상시키는 데 있다. 상호 문화적 능력은 의사소통 능력과 문화 능력의 기저로 작용하는 중요한 요소로써 외국어 학습 혹은 외국 문화와의 교류 시, 목표 언어와 문화의 습득을 위해 필수적으로 획득해야 하는 능력이다. 한편 ‘흥’은 즐거움, 기쁨, 상쾌함과 같은 긍정적이고 즐거운 기분을향유하는 데서 오는 양(陽)의 정서로 한국인의 사회・역사・문화적 배경 아래 형성되어 한국인의 정신세계나 일상생활 속에 많이 내재되어있다. 본고에서는 한국어 학습자의 상호 문화적 능력 향상을 위해서한국 정신문화의 한 요소인 ‘흥’을 이해할 필요가 있다고 보고, 대상텍스트로 한국의 고전 판소리인 <흥부가> 및 시조, 가사, 잡가, 민요등의 고전 문학 제재를 선정하여 대상과의 교감을 통한 흥, 즉흥적 성격으로서의 흥, 낙관적 성격으로서의