Hye‐Ryun Kang
서울대학교 의과대학 · 의학
Hye-Ryun Kang 교수의 연구실은 폐 섬유화 및 만성 폐질환의 발달 기전을 규명하는 데 초점을 맞추고 있습니다. 특히 TGF-β1이 유도하는 섬유화, 세포 사멸, 그리고 조직 재구성 과정에서 핵심적으로 작용하는 분자인 SEMA 7A와 Bax를 포함한 사멸 신호전달 경로의 기능을 중심으로 연구를 진행하고 있습니다. 또한 약물 유발 알레르기 반응, 특히 조영제 및 세팔로스포린에 의한 쇼크 반응의 기전과 위험 요인에 대해서도 꾸준히 연구하고 있습니다. 환경 흡연 노출이 어린이의 호흡기 질환에 미치는 영향에 대해서도 예방적 접근을 모색하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Fibrosis, apoptosis, and the exaggerated production of transforming growth factor (TGF)-beta(1) are juxtaposed in a variety of pulmonary diseases including the interstitial lung diseases and asthma. In these disorders, the relationships between these responses are not well defined. In addition, the apoptosis pathways that contribute to these responses and the mechanism(s) of their contribution have not been described. We hypothesized that BH3 domain-only protein-induced apoptosis plays an import
Semaphorin (SEMA) 7A regulates neuronal and immune function. In these studies, we tested the hypothesis that SEMA 7A is also a critical regulator of tissue remodeling. These studies demonstrate that SEMA 7A and its receptors, plexin C1 and beta1 integrins, are stimulated by transforming growth factor (TGF)-beta(1) in the murine lung. They also demonstrate that SEMA 7A plays a critical role in TGF-beta(1)-induced fibrosis, myofibroblast hyperplasia, alveolar remodeling, and apoptosis. TGF-beta(1)
Overall, our data suggest that SJS, and TEN are infrequent but constantly arise throughout the years.
RCM induced anaphylactic shock is related to multiple exposures to RCM and most patients showed skin test positivity to RCM.
The prevalence of respiratory symptoms increased in children exposed to parental smoking including SHS and THS. To avoid the risk of respiratory and allergic disease by environmental tobacco smoke, absolute smoking cessation by parents is strongly recommended.
The incidence of cephalosporin-induced anaphylaxis differed according to individual drugs and side-chain structure. Screening IDT showed no clinical efficacy at a population level.
The incidence trend of anaphylaxis in Asia is not well investigated. The aim of this study is to estimate the entire population-based incidence of anaphylaxis in Korea using a nationwide administrative database.Data over a 7-year period (2008-2014) was obtained from the Korean National Health Insurance (NHI) claims database which covers 97.9% of the entire Korean population. Using diagnosis codes from the International Classification of Diseases-10 for anaphylaxis (T78.0, T78.2, T80.5, and T88.6
Platinum compounds are the most commonly reported causative agents of in-hospital drug-induced anaphylaxis. Older age ≥70 years and drugs such as iodinated contrast media and aminosteroid NMBA are related with high risk of anaphylactic shock.
