고려대학교 · Agricultural and Biological Sciences
Hyun Jin Park 교수의 연구실은 주로 약물 및 생물활성 성분의 안정성과 생체이용률을 향상시키기 위한 나노 및 마이크로 캡슐화 기술을 중심으로 연구를 진행하고 있습니다. 특히, 콜로이드계 시스템인 나노에멀션, 리포좀, 코팅된 마이크로스피어 등을 활용해 영양소나 약물의 방출 메커니즘을 제어하고, 식품 및 의약품 분야에 적용 가능한 고안정성 캡슐화 시스템을 개발하고 있습니다. 다양한 캡슐화 기법(스프레이 드라이닝, 고압 혼화, 공침법 등)을 응용하여 기능성 물질의 손실을 최소화하고, 약리적 활성과 안정성을 동시에 확보하는 데 초점을 맞추고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
ABSTRACT Microencapsulation involves the incorporation of food ingredients, enzymes, cells, or other materials in small capsules. Microcapsules offer food processors a means with which to protect sensitive food components, ensure against nutritional loss, utilize otherwise sensitive ingredients, incorporate unusual or time-release mechanisms into the formulation, mask or preserve flavors and aromas, and transform liquids into easily handled solid ingredients. Various techniques are employed to f
Curcumin nanoemulsions (Cur-NEs) were developed with various surfactant concentrations by using high pressure homogenization and finally applied to the commercial milk system. Characterization of Cur-NEs was performed by measuring the droplet size and polydispersity index value at different Tween 20 concentrations. The morphology of the Cur-NEs was observed by confocal laser scanning microscopy and transmission electron microscopy. Antioxidant activity and in vitro digestion ability were tested
Abstract The present study reports on the preparation of chitosan–tripolyphosphate (TPP) microspheres by the spray‐drying method using acetaminophen as a model drug substance. Chitosan–TPP microspheres were spherical and had a smooth surface. Perfectly spherical chitosan–TPP microparticles loaded with acetaminophen were obtained in the size range of 3.1–10.1 µm. Spray‐dried chitosan–TPP microspheres were positively charged (zeta potential ranged from +18.4 to +31.8). The encapsulation efficiency
