김현경 교수

A strategy is adopted that applies the mean meridional circulation (MMC) equation to two different steady states of a primitive equation model. This allows for the investigation of the mechanisms behind the sensitivity of the Hadley cell structure to individual source terms in an axisymmetric circulation. Specifically, the strategy allows the MMC response to the individual source terms to be partitioned into direct and indirect components.

This paper investigates the effect of baroclinic eddies on the structure of the Hadley cell. Self-consistent calculations of both axisymmetric and nonaxisymmetric circulations allow an unambiguous estimate of baroclinic eddy effects on the structure of the Hadley cell. Furthermore, a diagnostic analysis allows us to partition the influence of baroclinic eddies into "direct" and "indirect" responses. The former refers to the meridional circulation attributable to the explicit eddy fluxes while th

Retinoic acid receptor-related orphan receptor-α (RORα) is a member of the orphan nuclear receptor family and functions as a transcriptional activator in response to circadian changes. Circadian rhythms are complex cellular mechanisms regulating diverse metabolic, inflammatory, and tumorigenic gene expression pathways that govern cyclic cellular physiology. Disruption of circadian regulators, including RORα, plays a critical role in tumorigenesis and facilitates the development of inflammatory h

Janus tyrosine kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signaling pathway is essential for modulating cellular development, differentiation, and homeostasis. Thus, dysregulation of JAK2-STAT3 signaling pathway is frequently associated with human malignancies. Here, we provide evidence that lysine-specific demethylase 3A (KDM3A) functions as an essential epigenetic enzyme for the activation of JAK2-STAT3 signaling pathway. KDM3A is tyrosine-phosphorylated by JAK2

The acaricidal activity of materials derived from rhizome of Atractylodes ovata (Atractylodes macrocephala) toward adult Dermatophagoides farinae and Dermatophagoides pteronyssinus was examined using fabric-circle residual contact and vapor-phase toxicity bioassays. Results were compared with those of the currently used acaricides: benzyl benzoate, dibutyl phthalate, and N,N-diethyl-m-toluamide (Deet). The active principles of A. ovata rhizome were identified as the sesquiterpenoids, atractyleno

The acaricidal activities of materials derived from the root bark of Paeonia suffruticosa against adults of Dermatophagoides farinae and Dermatophagoides pteronyssinus were examined using direct contact and fumigation bioassays and compared with those of benzyl benzoate, dibutyl phthalate, and N,N-diethyl-m-toluamide (deet), widely used acaricides. The active constituents of Paeonia root bark were identified as paeonol and benzoic acid by spectroscopic analyses. On the basis of 24-h LD50 values,

Autophagy is a highly conserved mechanism responsible for cellular homeostasis and integrity in a variety of physiological conditions. Materials targeted for degradation are directed to autophagosomes and autolysosomes, where they are broken down into their base components. Aberrant regulation of autophagy is significantly associated with various cancers and neurodegenerative diseases. Recently, accumulating evidence has revealed that the coordinated regulation of histone and non-histone protein

The result of this study revealed little decrease in positive rate of C. sinensis compared with the result of southern endemic areas of Korea in 2006.

Methylation is a major post-translational modification (PTM) generated by methyltransferase on target proteins; it is recognized by the epigenetic reader to expand the functional diversity of proteins. Methylation can occur on specific lysine or arginine residues localized within regulatory domains in both histone and nonhistone proteins, thereby allowing distinguished properties of the targeted protein. Methylated residues are recognized by chromodomain, malignant brain tumor (MBT), Tudor, plan

Abstract : An important aspect of qualitative spatial reasoning is understanding mechanisms. This paper presents a qualitative analysis of motion for mechanical linkages. In particular, we describe how to analyze the behavior of a mechanism which has a movable axis. The basic idea of our approach is to represent relative motions of the link in terms of quadrants (qualitatively representing the direction relative to a global reference frame) and relative inclinations relative to the x-axis. Using