Hyun Soo Kim
성균관대학교 의과대학 · 의학
Hyun Soo Kim 교수의 연구실은 신경암, 간세포암 등 악성 종양의 유전체적 기반 메커니즘을 밝히는 데 초점을 맞추고 있습니다. 특히, 미세RNA, 유전자 발현, DNA 메틸화 등 다차원 유전체 데이터를 통합 분석하여 암에서 기능적으로 중요한 유전자 조절 네트워크를 규명하고 있습니다. 또한 만성질환과 관련된 대사 재편성, 특히 플루이디 템스템세포의 대사 특성과 다능성 유지 메커니즘에 대해서도 깊이 있는 연구를 수행하고 있습니다. 이와 같은 다학제적 접근을 통해 암의 발병 기전을 규명하고, 새로운 치료 타겟을 제시하고자 합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Using a multidimensional genomic data set on glioblastoma from The Cancer Genome Atlas, we identified hsa-miR-26a as a cooperating component of a frequently occurring amplicon that also contains CDK4 and CENTG1, two oncogenes that regulate the RB1 and PI3 kinase/AKT pathways, respectively. By integrating DNA copy number, mRNA, microRNA, and DNA methylation data, we identified functionally relevant targets of miR-26a in glioblastoma, including PTEN, RB1, and MAP3K2/MEKK2. We demonstrate that miR-
Pluripotent stem cells (PSCs) have distinct metabolic properties that support their metabolic and energetic needs and affect their stemness. In particular, high glycolysis is critical for the generation and maintenance of PSCs. However, it is unknown how PSCs maintain and acquire this metabolic signature. In this study, we found that core pluripotency factors regulate glycolysis directly by controlling the expression of glycolytic enzymes. Specifically, Oct4 directly governs Hk2 and Pkm2, which
Gallbladder carcinoma is the most common malignancy of the biliary tract in Korea and known to be more common in East Asia and Latin America than in Europe and North America. However, their exact histopathological characteristics and carcinogenesis are not well-elucidated. A total of 71 cases of gallbladder carcinomas, two cases of gallbladder dysplasia and 20 cases of gallbladder adenoma were immunohistochemically studied to evaluate the expression of c-erb-B2 and p53 proteins in the light of t
