Ik‐Kyung Jang
경희대학교 의예과 · 의학
이 교수의 연구실은 혈관 내 영상 기술, 특히 옵티컬 코herence 단층촬영(OCT)을 활용해 심장 혈관 질환의 병태생리학적 기전을 규명하는 데 집중하고 있습니다. 특히 급성 coronary 증후군(ACS)의 원인 중 하나인 플라크 융해(plaque erosion)의 진단 및 치료 전략 개발에 주력하며, 기존의 스텐트 치료와는 다른 맞춤형 관리 전략의 필요성을 제시하고 있습니다. 이와 함께 혈관 생물학, 스텐트 혈전증, 비차단 관상동맥에서의 심근경색 등 다양한 병변의 메커니즘에 대한 심층 연구를 수행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
For patients with ACS caused by plaque erosion, conservative treatment with anti-thrombotic therapy without stenting may be an option.
Pathology and in vivo imaging studies have identified superficial plaque erosion as a frequent and important mechanism underlying acute coronary syndromes (ACS). In contrast with plaque rupture, the pathophysiological mechanisms leading to plaque erosion remain poorly understood. The advent of intravascular imaging techniques, particularly optical coherence tomography, has aided understanding of this mode of ACS in vivo by complementing previous insights from pathology studies. Appreciation of t
IVUS (A) and OCT (B) images of the stented right coronary artery are shown.Although IVUS showed a well-deployed stent, the detailed structure around the stent struts is not well visualized.In addition, OCT clearly visualized tissue prolapse between the stent struts (12 to 3 o'clock).The tissue prolapse occurred mainly in an area with lower OCT signal intensity, which is suggestive of a plaque with a large lipid content.
Compared with those with culprit plaque rupture, patients with acute coronary syndrome caused by culprit plaque erosion had a smaller number of nonculprit plaques and the lower levels of panvascular instability, affirming that distinct pathophysiologic mechanisms operate in plaque erosion and plaque rupture.
