北海道大学 · Medicine
이소아 요코타 교수의 연구실은 감염병의 조기 진단과 대량 스크리닝을 위한 비침습적 진단 기술 개발에 초점을 맞추고 있습니다. 특히 타액을 이용한 코로나19 바이러스(SARS-CoV-2) 진단의 정확성과 실용성을 입증하며, 자가 채취 타액이 비정상 증상이 없는 환자에서도 높은 민감도와 특이도를 보임을 규명했습니다. 연구는 PCR 기반 진단의 정확성과 비만성 검사의 유효성을 비교 분석함으로써, 감염병 확산 방지를 위한 실용적이고 효율적인 진단 전략을 모색하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Both NPS and saliva specimens had high sensitivity and specificity. Self-collected saliva specimens are valuable for detecting SARS-CoV-2 in mass screening of asymptomatic persons.
Abstract Background COVID-19 has rapidly evolved to become a global pandemic due largely to the transmission of its causative virus through asymptomatic carriers. Detection of SARS-CoV-2 in asymptomatic people is an urgent priority for the prevention and containment of disease outbreaks in communities. However, few data are available in asymptomatic persons regarding the accuracy of PCR testing. Additionally, although self-collected saliva has significant logistical advantages in mass screening,
Emerging evidences have shown the utility of saliva for the detection of SARS-CoV-2 by PCR as alternative to nasopharyngeal swab (NPS). However, conflicting results have been reported regarding viral loads between NPS and saliva. We conducted a study to compare the viral loads between NPS and saliva in 42 COVID-19 patients. Viral loads were estimated by the cycle threshold (Ct) values. SARS-CoV-2 was detected in 34 (81%) using NPS with median Ct value of 27.4, and 38 (90%) using saliva with medi
Ministry of Health, Labour and Welfare, Japan.
