Jae Hee Cho
연세대학교 의과대학 · 의학
Jae Hee Cho 교수의 연구실은 주로 간담도계 암, 특히 췌장암과 간문도암 치료에 초점을 맞춘 내 endoscopic 치료 기술 개발을 주요 연구 분야로 삼고 있습니다. 열 제어를 적용한 내시경 레이저 열교정술(EB-RFA, ID-RFA)을 통해 암 조직을 정밀하게 제거하고, 화학저항성과 관련된 전사인자 NRF2의 역할을 규명함으로써 치료 성공률 향상에 기여하고자 합니다. 또한, 신경엔도크린성 종양(pNETs)의 예후 분류 기준과 내 endoscopic 절차의 최적화 순서에 대한 임상적 연구도 진행 중입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
EB-RFA using a temperature controlled RFA catheter successfully ablates the bile duct wall without adverse events in a swine model.
Temperature-controlled ID-RFA for advanced MHBO was safe and feasible. It could prevent premature PS occlusion within 3 months.
Chemoresistance is a leading cause of morbidity and mortality in patients with pancreatic cancer and remains an obstacle to successful treatment. The antioxidant transcription factor nuclear factor (erythroid-derived 2)-related factor 2 (NRF2), which plays important roles in tumor angiogenesis and invasiveness, is upregulated in pancreatic ductal adenocarcinoma (PDAC), where it correlates with poor survival. Here, we investigated the role of NRF2 in two 5-Fluourouracil-resistant (5-FUR) PDAC cel
The AJCC and ENETS TNM classifications for pNETs are prognostic for PFS and can be adopted in clinical practice in South Korea.
EB-RFA partially ablated human cancer tissue and preoperative EB-RFA might be a safe and feasible in patients with distal extrahepatic cholangiocarcinoma who require a delayed operation. Ablation of the target lesion longer than the estimated length by fluoroscopy may improve the efficacy of EB-RFA.
The quality of EGD steps is influenced by the sequence of bidirectional endoscopy. EGD is perceived to be more stressful to patients when preceded by colonoscopy. Therefore, EGD followed by colonoscopy may be the preferable procedural sequence for same-day bidirectional endoscopy.
Our results suggest that the BRCA2 mutation may not contribute to increases in the risk for both sporadic and familial pancreatic cancer in Korea.
Pancreatic cancer stem cells (CSCs) play a crucial role in tumorigenesis and chemoresistance of pancreatic ductal adenocarcinoma. Pancreatic adenocarcinoma up-regulated factor (PAUF), a novel secretory protein, has been shown to contribute to cancer progression and metastasis. Because the clinical relationship between PAUF and pancreatic CSCs is largely unknown, we investigated the associations between the functional role of PAUF and pancreatic CSCs. Pancreatic cancer sphere cultured from the CF
