Jae‐Hong Ryoo
경희대학교 의예과 · 의학
Jae-Hong Ryoo 교수의 연구실은 대사증후군과 관련된 대사질환의 조기 발병 위험을 예측하고자, 비알코올성간지방증후군(NAFLD), 높은 혈중 요산 수치, 고혈압, 만성신질환 등 간 및 대사 관련 질환 간의 인과관계를 중심으로 연구를 진행하고 있습니다. 특히 한국 남성들을 대상으로 한 장기적 코hort 연구를 통해 NAFLD가 당뇨병, 고혈압, 만성신질환 등 다수의 만성질환의 전조증상으로서의 역할을 규명하고 있으며, 생체마커로서의 요산 수치의 임상적 의미에도 초점을 맞추고 있습니다. 이는 조기 진단 및 예방 전략 개발에 기여할 임상적 의미를 지닙니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The development of type 2 DM is potentially more associated with more progressive NAFLD than a normal or milder state. In addition, NAFLD was an independent risk factor for the future development of type 2 DM. These results suggest the potential availability of NAFLD as an early predictor of type 2 DM.
Development of hypertension is more potentially associated with the more progressive NAFLD than normal or milder state. In addition, NAFLD was an independent risk factor for hypertension.
There have been many studies between serum uric acid (UA) and chronic kidney disease (CKD). However, as far as we know, little research has been done to examine the prospective association between serum UA and development of CKD in Korean men. This prospective cohort study was performed using 18,778 men who participated in a health checkup program both on January, 2005 and on December, 2009. CKD was defined as an estimated glomerular filtration rate < 60 mL/min per 1.73 m(2). The odds ratio (OR)
MetS is a potential risk factor for pancreatic cancer. The presence of ≥4 metabolic components leads to a higher risk of pancreatic cancer even within categories of the MetS.
Previous epidemiologic studies have shown the clinical association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). However, there is only limited information about the effect of NAFLD on the development of hypertension. Accordingly, we investigated the clinical association between NAFLD and prehypertension. A prospective cohort study was conducted on the 11,350 Korean men without prehypertension for 5 yr. The incidences of prehypertension were evaluated, and C
Elevated serum UA level was independent risk factor for the development of microalbuminuria during a 5-year follow-up in Korean men.
Our findings show that serum γ-glutamyltransferase level could be a predictor of the development of insulin resistance in Korean men.
In this study, elevated ferritin concentration is independently associated with metabolic syndrome and its components among healthy Korean men.
Metabolic syndrome is a potential risk factor for cholelithiasis. Low HDL cholesterol level is the most relevant factor among MetS components for incident cholelithiasis.
In this study, apoB was found to be the most important determinant for the future development of CHD during a 5-year follow-up in healthy Korean men.
