연세대학교 · 치의학
Jae-Kook Cha 교수의 연구실은 치과 임플란트의 합병증인 퇴행성 주위치질염(peri-implantitis)의 치료 및 예방을 중심으로, 국소 항생제(미노시클린)와 수술적 치료의 융합, 비수술적 치료 전략(기계적 세정제 병용)의 효과를 체계적으로 연구하고 있습니다. 또한, 임플란트 식립 전 후보 부위의 뼈 보존 기술과 신경성 뼈 형성 단백질(BMP-2)을 활용한 뼈 재생 전략에 초점을 맞추며, 뼈 형성 촉진 및 임플란트 통합을 위한 생체모방적 기법 개발에 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The purpose of this study was to determine the clinical, microbial, and radiographic effects of local minocycline combined with surgical treatment of peri-implantitis. Fifty patients with peri-implantitis were recruited, and surgical treatment with the local application of either minocycline or placebo ointment was performed. The application of minocycline was repeated with supragingival debridement at 1, 3, and 6 mo postoperatively. Plaque index, gingival index (GI), probing pocket depth (PPD),
Alveolar ridge preservation in the posterior maxilla maintained the vertical bone height more efficiently and resulted in less need for sinus augmentation procedures at 6 months compared to spontaneous healing.
Within the limitations of this in vitro investigation, the tested protocols induced different macroscopic alterations and surface roughness changes that varied in the thread and valley area.
BMP-2 in a BHC carrier, even at the low 0.1-mg/ml concentration, induces osteogenic activity, enhancing local bone formation in a canine sinus model.
Additive use of either MM or MC results in significantly higher treatment success rates compared to sole mechanical debridement in nonsurgical treatment of peri-implantitis. Moreover, MM contributes to a significantly greater reduction in the PPD compared to MC in deep pockets (cris.nih.go.kr KCT0004557).
It was conjectured that intentional cortical perforation of the recipient bed and the ABB might enhance the initial angiogenesis and the integration of the graft.
It can be suggested that Osteon may have predictable result when it was used as a grafting material for sinus floor augmentation.
A wide restorative angle increases MBL and impairs the integrity of the junctional epithelium of the implant supracrestal complex.
Oral administration of MAEC would have a potential to reduce gingival inflammation clinically and immunologically in the patients with gingivitis and incipient periodontitis.
BCP can achieve proper dimensional stability with minimal reduction of the graft height in a 3- to 6-year healing period after maxillary sinus augmentation. The healing period and the amount of graft material influenced the resorption of BCP.
The osteogenic efficacy of BMP-2 on the regeneration of peri-implant bone defects was not detectable after 16 weeks regardless of the carrier materials.
The increase in soft-tissue dimensions for 1 year was similar between the two groups. The mucosal contour increase was larger when the surgery was conducted in a more contained defect, and this was not influenced by the type of BCP.
Due to the small sample size, this pilot study remains inconclusive. Within the limitations of the study, the use of CM and/or BS did not appear to have an additional benefit on lateral bone augmentation of peri-implant defect with TM.
