Jae‐Yong Park
고려대학교 바이오시스템의과학부 · 의학
Jae-Yong Park 교수의 연구실은 주로 암 발생 메커니즘과 관련된 유전적 소인 및 세포 사멸 경로에 초점을 맞추고 있습니다. 특히 캐스페이스-9, 클러스터린, COX-2 등의 유전자 다형성과 암 유병률 간의 연관성을 밝혀내는 분자유전자학적 연구를 진행하고 있으며, 난소암, 폐암, 위암 등에서의 유전자 및 미생물군집 변화를 분석합니다. 또한 뇌에서의 14-3-3γ 단백질의 기능과 관련된 신경계 질환 연구를 통해 뇌 발달 및 병태생리학적 메커니즘을 탐구하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Caspase-9 (CASP-9) is an initiator CASP in the apoptosome-driven apoptosis pathway and plays an important role in the development and progression of cancer. Polymorphisms in the promoter region of the CASP-9 gene may influence the promoter activity of this gene, thereby modulating susceptibility to lung cancer. To test this hypothesis, we examined the association of four polymorphisms [-1263A>G, -905T>G, -712C>T and -293_-275delCGTGAGGTCAGTGCGGGGA (-293del)] in the CASP-9 promoter with the risk
Clusterin (CLU), a glycoprotein, is involved in apoptosis, producing two alternatively spliced isoforms in various cell types. The pro-apoptotic CLU appears to be a nuclear isoform (nuclear clusterin; nCLU), and the secretory CLU (sCLU) is thought to be anti-apoptotic. The detailed molecular mechanism of nCLU as a pro-apoptotic molecule has not yet been clear. In the current study, overexpressed nCLU induced apoptosis in human kidney cells. Biochemical studies revealed that nCLU sequestered Bcl-
Although there is a growing interest in the role of gastric microbiome on the development of gastric cancer, the exact mechanism is largely unknown. We aimed to investigate the changes of gastric microbiome during gastric carcinogenesis, and to predict the functional potentials of the microbiome involved in the cancer development. The gastric microbiome was analyzed using gastric juice samples from 88 prospectively enrolled patients, who were classified into gastritis, gastric adenoma, or early/
The six-step operation of surface-mounted permanent magnet machine drives in a flux weakening region has many advantages compared to the pulse width modulation mode, such as the reduced switching loss and fully utilized inverter output voltage. However, if the ratio of the sampling frequency to the fundamental frequency is low in fixed sampling system, the low-frequency oscillation in the current can be incurred in the six-step operation. The low-frequency current causes a system stability probl
These findings suggest that the COX-2 8473T>C polymorphism could be used as a marker for the genetic susceptibility to adenocarcinoma of the lung.
14-3-3 proteins are mostly expressed in the brain and are closely involved in numerous brain functions and various brain disorders. Among the isotypes of the 14-3-3 proteins, 14-3-3γ is mainly expressed in neurons and is highly produced during brain development, which could indicate that it has a significance in neural development. Furthermore, the distinctive levels of temporally and locally regulated 14-3-3γ expression in various brain disorders suggest that it could play a substantial role in
