Jee In Kang
연세대학교 정신과학교실 · 심리학
이 교수의 연구실은 정신건강 및 암 관련 정서적 조절 메커니즘을 중심으로 신경생물학적 기전과 유전적 소인을 탐구하고 있습니다. 특히 외상 후 스트레스 장애(PTSD)와 불안성 장애의 유전자 메틸화 변화, BDNF 및 COMT 유전자 다형성이 정서적 회복력에 미치는 영향을 분석하며, 뇌자극 치료(rTMS)를 통한 정신질환 치료의 유효성과 안전성에 대해서도 연구하고 있습니다. 암 환자의 정서적 적응과 정신건강 문제의 조기 진단 및 관리 전략 개발에도 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Article AbstractObjective: The present study investigated possible therapeutic effects and safety of sequentially combined low-frequency repetitive transcranial magnetic stimulation (rTMS) to the right dorsolateral prefrontal cortex and supplementary motor area in patients with treatment-resistant obsessive-compulsive disorder. Method: Between February 2007 and January 2008, we carried out a study with a rater-blinded, sham-controlled design in which 20 patients with treatment-resistant obsessiv
This study demonstrated an association between higher DNA methylation of the BDNF promoter and PTSD diagnosis in combat-exposed individuals. Our findings suggest that altered BDNF methylation may be a valuable biomarker of PTSD after trauma exposure.
Mental adjustment and coping affect the physical outcome and survival as well as quality of life in cancer patients. The Mini-Mental Adjustment to Cancer (Mini-MAC) scale is a new refined, economical and reliable self-rating instrument measuring cognitive and behavioral responses to cancer. The aim of this study was to evaluate the psychometric properties of the Mini-MAC in Korean cancer patients. A total of 208 cancer patients recruited from the Yonsei Cancer Center were assessed with the Mini-
ClinicalTrials.gov identifier: NCT01325831.
The incidence rates of psychiatric disorders in Korean women with breast cancer from the nationwide database were much lower than found by previous reports using screening tools. The finding implicates that psychiatric disorders among breast cancer patients tend to be underdiagnosed and undertreated in actual clinical practice. Our epidemiological findings provide important information for establishing a national strategy of cancer care to detect and manage psychiatric problems.
These findings suggest the effects of COMT Val158Met polymorphism on resilience could be modulated by BDNF Val66Met polymorphism in males.
Altered GABAergic transmission and/or the imbalance of inhibitory and excitatory systems in the striatum may be present at the putative prodromal stage and play a pivotal role in the pathophysiology of psychosis.
These findings suggest that disgust sensitivity may be affected by genetic components, such as dopamine-related genes.
