Jeong Wook Lee
포항공과대학교 생명과학과 · 생화학·유전·분자생물학
이 교수의 연구실은 생물학적 분자 기반의 혁신적 기술 개발에 초점을 맞추고 있습니다. 특히 DNA 저장 기술, RNA 바이러스 진단 기술, 그리고 생물학적 색소인 비올라신의 대량 생산을 위한 대사 공학 기술을 핵심 연구 분야로 다룹니다. 또한, 수분 및 미세먼지 제거에 효과적인 수성 및 초수성 표면 재료 개발을 통해 환경 및 의료 분야의 실용적 응용을 추구합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The raw data files and the source codes of our experiments are available at: https://github.com/jhjeong0702/dna-storage.
Mannheimia succiniciproducens MBEL55E isolated from bovine rumen is an industrially important bacterium as an efficient succinic acid producer. Recently, its full genome sequence was determined. In the present study, we analyzed the M. succiniciproducens proteome based on the genome information using 2-DE and MS. We established proteome reference map of M. succiniciproducens by analyzing whole cellular proteins, membrane proteins, and secreted proteins. More than 200 proteins were identified and
A rapid, sensitive and simple point-of-care (POC) nucleic acid diagnostic test is needed to prevent spread of infectious diseases. Paper-based toehold reaction, a recently emerged colorimetric POC nucleic acid diagnostic test, has been widely used for pathogen detection and microbiome profiling. Here, we introduce an amplification method called reverse transcription loop-mediated amplification (RT-LAMP) prior to the toehold reaction and modify it to enable more sensitive and faster colorimetric
In the last few decades, numerous studies have focused on designing suitable hydrophilic materials to inhibit surface-induced fog or frost under extreme conditions. As fogging and condensation frosting on a film involves molecular interaction with water prior to forming discrete droplets on the surface, it is essential to control the extent of a film to strongly bind with water molecules for antifogging coatings. While the water contact angle measurement is commonly used to probe the hydrophilic
Violacein is a naturally occurring purple pigment, widely used in cosmetics and has potent antibacterial and antiviral properties. Violacein can be produced from tryptophan, consequently sufficient tryptophan biosynthesis is the key to violacein production. However, the complicated biosynthetic pathways and regulatory mechanisms often make the tryptophan overproduction challenging in <i>Escherichia coli</i>. In this study, we used the adaptive laboratory evolution (ALE) strategy to improve viola
