Jeong‐Won Lee
성균관대학교 의과대학 · 의학
이 교수의 연구실은 난소세포암을 비롯한 다양한 암의 악성 전환 메커니즘과 약물 내성 극복 전략을 중심으로 연구를 진행하고 있습니다. 특히 miRNA의 기능 이상, Sphingosine kinase 1(SK1)의 발현 조절, 그리고 항암제 조합(예: 클로로퀸과 시스플라틴)을 통한 세포 사멸 유도 및 DNA 손상 반응 조절에 초점을 맞추고 있습니다. 이는 암 치료의 새로운 표적과 치료 전략 개발에 기여할 잠재력을 지닌 분야입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Our results show that miRNA deregulation may play an important role in the malignant transformation of cervical squamous cells. In addition, they may offer new candidate targets to be exploited for both prognostic and therapeutic strategies in patients with cervical cancer.
The 1C1-mcMMAF immunoconjugate had antitumor activity in preclinical models of ovarian carcinoma.
Overcoming drug-resistance is a big challenge to improve the survival of patients with epithelial ovarian cancer (EOC). In this study, we investigated the effect of chloroquine (CQ) and its combination with cisplatin (CDDP) in drug-resistant EOC cells. We used the three EOC cell lines CDDP-resistant A2780-CP20, RMG-1 cells, and CDDP-sensitive A2780 cells. The CQ-CDDP combination significantly decreased cell proliferation and increased apoptosis in all cell lines. The combination induced expressi
Sphingosine kinase 1 (SK1) is over-expressed in multiple types of human cancer. SK1 has growth-promoting effects and has been proposed as a potential therapeutic target. We investigated the therapeutic effects of SK1 inhibition in epithelial ovarian carcinoma (EOC). SK1 siRNA or inhibitors were tested in EOC cell lines, including A2780, SKOV3ip1, A2780-CP20, SKOV3-TR, ES2 and RMG2. Cells were treated with SK inhibitor or FTY720, and cell proliferation, apoptosis, angiogenesis and invasion were e
