Ji Hye Kim
성균관대학교 의과대학 · 생화학·유전·분자생물학
Ji Hye Kim 교수의 연구실은 주로 피부 건강과 노화 방지에 기여하는 천연물 성분의 생리적 기전을 규명하는 데 초점을 맞추고 있습니다. 특히 인삼 유래 물질, 항염증 및 항산화 작용을 보이는 화합물들이 피부 손상, 염증, 노화 관련 병변에 미치는 영향을 분자생물학적·세포생물학적 방법으로 연구하고 있습니다. 또한, 단백질 메틸화 효소와 microRNA를 통한 유전자 조절 메커니즘을 통해 피부질환 및 간세포암과 같은 질병의 발달 기전을 밝히는 데 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Protein arginine methyltransferases (PRMTs) mediate the methylation of a number of protein substrates of arginine residues and serve critical functions in many cellular responses, including cancer development, progression, and aggressiveness, T-lymphocyte activation, and hepatic gluconeogenesis. There are nine members of the PRMT family, which are divided into 4 types (types I-IV). Although most PRMTs do not require posttranslational modification (PTM) to be activated, fine-tuning modifications,
These results strongly suggest that the anti-inflammatory action of PPD-SF could be mediated by a reduction in the activation of p38-, JNK2-, and TANK-binding-kinase-1-linked pathways and their corresponding transcription factors (ATF2 and IRF3).
This study demonstrates the protective effects of GrDENs against skin damage caused by UV and oxidative stress, providing new insights into beneficial uses of ginseng<b>.</b> In particular, our results suggest GrDENs as a potential active ingredient in cosmeceuticals to promote skin health.
SYR showed antioxidant activity and up-regulated autophagy activity in H<sub>2</sub>O<sub>2</sub>-stimulated HaCaT cells, lowering the expression of MMP-2 and MMP-9 associated with skin aging. Our results suggest that SYR has potential value as a cosmetic additive for prevention of skin aging.
PPT improves skin barrier function and hydration through Src/AKT/NF-κB and MAPK signaling. Therefore, PPT may be a valuable component for cosmetics or treating skin disorders.
Several studies have reported reduced miR-199a-3p expression in hepatocellular carcinoma (HCC). In an effort to discover important target genes for miR-199a-3p that may be related to HCC development or progression, we identified the tetraspanin, transmembrane glycoprotein CD151. Luciferase reporter assays and western blotting identified CD151 as a bona fide miR-199a-3p target gene. While CD151 protein was increased in the mesenchymal but not the epithelial HCC cell lines, CD151 knockdown with si
