서지훈 교수

The rapid response of integrin β1 molecules to an RGD peptide on a dynamic polyrotaxane surface was successfully induced. As a result, RGD peptides introduced on a highly dynamic cyclodextrin molecule enhanced the frequency of contact with specific integrin molecules on the cell membrane at the early stage of material-cell interactions.

Polymer surfaces with a wide range of hydrated surface mobility are developed by a simple deposition method with supramolecular block copolymers. The morphologies of adhering stem cells are greatly dependent on the surface mobility of polymers, and this induces significant changes in the cytoskeletal signaling pathway to direct the downstream stem cell differentiation.

Abstract Polymer plastic crystal electrolytes (PPCEs) have garnered significant attention for addressing the challenges associated with succinonitrile (SN), including its inadequate mechanical properties and side reactions with electrodes. However, a comprehensive investigation of the influence of the molecular structure of the polymer network on the states of SN within the network and its subsequent impact on ionic conductivities remains largely unexplored. To shed light on this critical aspect

A UV-cleavable supramolecular cross-linker was designed to effectively control the mechanical strength of photocurable resin plastics. The resin monomer-soluble polyrotaxane (PRX) cross-linker was synthesized by introducing a hydrophobic <i>n</i>-butyl group and a cross-linkable methacrylate group in α-cyclodextrin threading to a polyethylene glycol containing UV-cleavable end groups. The UV-cleavable PRX cross-linker was completely dissolved in 2-hydroxyethytl methacrylate (HEMA) and camphorqui

A conductive elastomer is stretchable and can exhibit ionic or electrical conductivity. However, its resistivity increases exponentially when a small number of strain changes are provided owing to irreversible internal deformation. Therefore, securing a wide range of linearity in the resistance–strain relationship is an important topic in the preparation of highly reliable conductive elastomers. Herein, an ionic conductive elastomer is prepared using 2-methoxyethyl acrylate (MA) and a molecular

The network structures of liquid crystal elastomers (LCEs) are crucial to impart rubbery behavior to LCEs and enable reversible actuation. Most LCEs developed to date are covalently linked, implying that the cross-links are fixed at a particular position. Herein, we report a new class of LCEs integrating polyrotaxanes (PRs) as slidable cross-links (PR-LCEs). Interestingly, the incorporation of a low loading (0.3-2.0 wt %) of the PR cross-linkers to the LCE causes a significant impact on various

Increasing molecular mobility of hydrated polyrotaxane (PRX)-coated surfaces was effective to promote the differentiation of mouse induced pluripotent stem cells (iPS cells) into cardiomyocytes.