Kyushu University · 공학
미와카키 씨의 연구실은 단일벽 탄소 나노호른(SWNHs)을 중심으로 한 나노소재의 합성, 생체적합성 평가 및 응용 기술을 연구하고 있습니다. 특히 약물 전달 시스템에서의 생체 내 분포와 초미세 구조적 국소화를 정량적으로 분석할 수 있는 기반 기술을 개발하며, 자기공명영상(MRI)을 활용한 비침습적 영상 기반 추적 기술과도 융합하고 있습니다. 또한, 나노호른 내부에 고체 반응을 유도하는 나노콘finement 효과를 활용해 초미세 산화 gadolinia 나노입자를 안정적으로 생성하는 고온 반응 공정도 확립하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
We extensively investigated in vitro and in vivo the toxicities of as-grown single-walled carbon nanohorns (SWNHs), a tubular nanocarbon containing no metal impurity. The SWNHs were found to be a nonirritant and a nondermal sensitizer through skin primary and conjunctival irritation tests and skin sensitization test. Negative mutagenic and clastogenic potentials suggest that SWNHs are not carcinogenic. The acute peroral toxicity of SWNHs was found to be quite low--the lethal dosage for rats was
Nanoparticles of superparamagnetic magnetite have been strongly attached to single-walled carbon nanohorns (SWNHs) by using a simple method, namely the deposition of iron acetate clusters on SWNHs followed by heat treatment. The attached magnetite nanoparticles induce remarkable darkening of the magnetic resonance images, which allowed in vivo visualization (see figure) of the accumulative behavior of SWNHs in the spleen and kidneys. Supporting information for this article is available on the WW
Single-walled carbon nanohorns (SWNHs) are single-graphene tubules that have shown high potential for drug delivery systems. In drug delivery, it is essential to quantitatively determine biodistribution and ultrastructural localization. However, to date, these determinations have not been successfully achieved. In this report, we describe for the first time a method that can achieve these determinations. We embedded Gd(2)O(3) nanoparticles within SWNH aggregates (Gd(2)O(3)@SWNHag) to facilitate
The methane adsorption of water-preadsorbed carbons of different micropore widths w at 303 K was measured. Although the amount of adsorption of supercritical methane on microporous carbon at 303 K was less than 9.4 mg g-1 at 101 kPa, the presence of the preadsorbed water enhanced noticeably the methane adsorption at 303 K even under subatmospheric pressure. The adsorption increment of methane reached a maximum at 1−2 h after introduction of methane and decreased gradually to a steady value after
The large diameter of single-wall carbon nanohorns (SWNHs) allows various molecules to be easily incorporated in hollow nanospaces. In this report, we prove that the nanospaces of SWNHs even work as the chemical reaction field at high temperature; that is, Gd-acetate clusters inside SWNHs were transformed into ultrafine Gd(2)O(3) nanoparticles with their particle size retained even after heat-treatment at 700 degrees C. This indicates that the confinement of the Gd-acetate clusters in a deep pot
