성균관대학교 · Materials Science
Jin Yong Lee 교수의 연구실은 주로 광학적 및 전기화학적 특성을 가진 유기 분자 센서를 설계하고, 이를 바탕으로 특정 이온·분자(예: Cu²⁺, KCN, Hcy, F⁻ 등)를 고도로 선택적으로 감지하는 신호 전환형 센서를 개발하고 있습니다. 특히, DFT/TDDFT 계산을 통한 전자 구조 분석을 바탕으로 감지 메커니즘을 정량적으로 규명하며, 생체 내 이미징 및 에너지 장치 응용까지 확장하는 연구를 수행하고 있습니다. 주요 응용 분야로는 생물학적 샘플 내 금속 이온 모니터링과 연료전지의 비백금 전기촉매 개발도 포함됩니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Showing their true colors: Polymers based on polydiacetylene and imidazolium show selective color response to anionic surfactants. Furthermore, this system easily distinguishes between the anionic surfactants sodium dodecyl sulfate (SDS) and sodium dodecylbenzenesulfonic acid (SDBS).
An indole conjugated coumarin 1 for KCN chemodosimeter has been prepared and displayed considerable dual changes in both absorption (blue-shift) and emission (turn-on) bands exclusively for KCN. DFT/TDDFT calculations support that the fluorescence enhancement of 1-KCN is mainly due to blocking of the ICT process.
The recent advances in platinum-free and/or metal-free electrocatalysts for electrochemical redox reactions at the electrodes of fuel cells in particular and, broadly speaking, energy devices were thoroughly reviewed. This comprehensive review focuses on nonplatinum precious metal (Pt-free) and/or nonprecious metal (metal-free) electrocatalysts regarding the electrochemical redox reactions at the electrodes of the energy devices. The recent development of electrocatalysts governing the electroch
A rationally designed, coumarin-based fluorescent sensor imino-coumarin (IC) displays high selectivity for Cu(2+) over a variety of competing metal ions in aqueous solution with a significant fluorescence increase. DFT/TDDFT calculations support that the fluorescence 'turn-on' of IC originates from blocking the electron transfer of the nitrogen lone pair upon complexation with Cu(2+). IC was successfully applied to microscopic imaging for detection of Cu(2+) in LLC-MK2 cells (in vitro) and sever
The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.
A new naphthalene derivative containing a urea group at the 1,8-position of naphthalene was synthesized and showed a unique absorption and fluorescence peak with fluoride ion. Calculations suggested that a new peak was attributed to the increased anionic character of urea nitrogen due to the strongly charged hydrogen bonding between fluoride and amide protons of the urea. The fluoride selectivity among halides (F(-), Cl(-), Br(-)) comes from the fact that the fluoride approaches much closer to t
Abstract Precise control of the local electronic structure and properties of electrocatalysts is important for enhancing the multifunctionality and durability of electrocatalysts and for correlating the structure/chemistry with the catalytic properties. Herein, we report electronically coupled metallic hybrids of NiFe layered double hydroxide nanosheet/Ti 3 C 2 MXene quantum dots deposited on a nitrogen‐doped graphene surface (LDH/MQD/NG) for high‐performance flexible Zn–air batteries (ZABs). As
A coumarin-based derivative (1), a highly selective and sensitive turn-on fluorogenic probe for the detection of HSO4- ions in aqueous solution, has been designed and synthesized. Various spectroscopic and DFT calculations revealed that H-bonding between the phenolic -OH and imine nitrogen of 1 played a crucial role in its high selectivity for HSO4-.
The development of activatable photosensitizers to allow for the reversible control of singlet oxygen (<sup>1</sup>O<sub>2</sub>) production for photodynamic therapy (PDT) faces great challenges. Fortunately, the flourishing field of supramolecular biotechnology provides more effective strategies for activatable PDT systems. Here, we developed a new reversible PDT on a switch that controls the <sup>1</sup>O<sub>2</sub> generation of self-assembled albumin nanotheranostics in vitro and in vivo. A
Despite being a clinically approved intervention for cancer, photodynamic therapy (PDT) still suffers from limitations. Prime among these is a therapeutic response that is mostly oxygen dependent. This limits the utility of PDT in treating hypoxic tumors since lower levels of cytotoxic reactive oxygen species (ROS) are generated in regions of low oxygen tension. Glutathione-pi (GST-pi) is a key enzyme that militates against ROS-mediated apoptosis. We report herein a new construct, EA-BPS, that c
