Jinheung Kim
이화여자대학교 생화학과 · 생화학·유전·분자생물학
김진흥 교수의 연구실은 비헤모 철 복합체를 중심으로 한 촉매 반응 메커니즘과 반응 중간체의 규명을 핵심으로 하며, 특히 알케인 기능화, 과산화물과의 반응을 통한 산화 반응, 그리고 광촉매를 활용한 이산화탄소의 포름산 전환에 초점을 맞추고 있습니다. 전자스핀 공명(EPR), 라만 스펙트로스코피, 전이 상태 분석 및 전기화학적 질량분석을 활용한 단기 중간체의 동정 기법을 응용하여, 금속 기반 산화 반응과 라디칼 체인 반응 간의 메커니즘 차이를 규명하고 있습니다. 또한, 이온 검출을 위한 플루오레스센스 센서 및 G-구조 형성 기반의 생물분석 기법 개발도 함께 진행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Catalytic alkane functionalization by the Fe(TPA)/tBuOOH system (with [Fe(TPA)Cl2]+ (1), [Fe(TPA)Br2]+ (2), and [Fe2O(TPA)2(H2O)2]4+ (3) as catalysts; TPA = tris(2-pyridylmethyl)amine) has been investigated in further detail to clarify whether the reaction mechanism involves a metal-based oxidation or a radical chain autoxidation. These two mechanisms can be distinguished by the nature of the products formed, their dependence on O2 (determined from argon purge and 18O2 labeling experiments), and
Based on EPR, Raman, and mass spectral evidence, the formula 1 best describes the transient intermediate which forms upon treatment of 2 with tert-butyl hydroperoxide in the presence of alcohol. Kinetic evidence suggests that its decomposition by oxidation of the bound alcohol proceeds via the transition state 3. tpa = tris(2-pyridylmethyl)amine.
The efficient and selective light-driven conversion of carbon dioxide to formate is a scientific challenge for green chemistry and energy science, especially utilizing visible-light energy and earth-abundant catalytic materials. In this report, two mononuclear Ni(II) complexes of pyridylbenzimidazole (pbi) and pyridylbenzothiazole (pbt), such as Ni(pbt)(pyS)<sub>2</sub> (<b>1</b>) and Ni(pbi)(pyS)<sub>2</sub> (<b>2</b>) (pyS = pyridine-2-thiolate), were prepared and their reactivities studied. T
A homogeneous assay is reported using Ru(phen)(2)(dppz)(2+) and a K(+)-binding aptamer for the selective and sensitive detection of a target oligonucleotide and potassium ions, based on reduction in fluorescence emission according to the formation of the G-quadruplex structure from the aptamer in the presence of K(+).
The selective assay of aluminum and cyanide ions is reported using fluorescence enhancement and quenching of a phenol–naphthol based chemosensor (PNI) in aqueous and nonaqueous solvents, respectively.
Strategies have been developed to obtain electrospray ionization mass spectral data on short-lived intermediates derived from the reactions of non-heme iron complexes with peroxides. The molecular composition of a transient green intermediate generated from [Fe(2)O(5-Me(3)-TPA)(2)(OH)(H(2)O)](ClO(4))(3) with H(2)O(2) in CH(3)CN at -40 degrees C was determined by introducing the solution via a precooled syringe to the inlet of the mass spectrometer. The observation of prominent ion clusters in bo
