東京工業大学 · Materials Science
최호 교수의 연구실은 나노구조 이중수화물(LDH), 특히 마그네슘/알루미늄 기반 이중수화물을 핵심 소재로 활용하여 생체분자와의 하이브리드를 통해 약물 및 유전자 전달 시스템을 개발하고 있습니다. 생분해성 및 비세포독성 특성을 가진 이물질 기반 나노소재를 활용해 치료제의 정밀한 배달과 환경에 친화적인 녹색 소재를 동시에 실현하고자 합니다. 또한, ZnO 나노나선 등의 광학적·전기적 기능성을 가진 나노소재의 합성 및 응용 연구도 병행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTIntercalative Nanohybrids of Nucleoside Monophosphates and DNA in Layered Metal HydroxideJin-Ho Choy, Seo-Young Kwak, Jong-Sang Park, Yong-Joo Jeong, and Josik PortierView Author Information Department of Chemistry, Center of Molecular Catalysis Seoul National University, Seoul, 151-742, Korea Institut de Chimie de la Matière, Condensée de Bordeaux 33608 Pessac, France Cite this: J. Am. Chem. Soc. 1999, 121, 6, 1399–1400Publication Date (Web):Feb
A biomolecular–inorganic hybrid is formed from anionic biomolecules (such as DNA fragments, ATP, or an antisense oligonucleotide) intercalated in a cationic Mg/Al layered double hydroxide (see picture). Such a hybrid can be used to deliver drugs or genes from the inorganic noncytotoxic carrier. Cellular uptake experiments confirm this, with the carrier dissolving slowly in a leukemia cell, and thereby releasing its growth-inhibiting load.
A high‐quality ZnO nanorod array (NRA) has been successfully grown on a Si wafer by a wet‐chemical process, where the Si wafer was dip‐coated with 4 nm sized ZnO nanoparticles as a buffer and seed layer prior to the crystal growth. It is found that the as‐prepared ZnO NRA has a threshold power density of ∼ 70 kW cm –2 , which is comparable to the lowest one determined for ZnO NRAs on Al 2 O 3 substrates (40 kW cm –2 ). The ultraviolet lasing efficiency of the ZnO NRAs is thus similar for both su
Eine bioorganisch-anorganische Hybridverbindung wird aus anionischen Biomolekülen gebildet (z. B. DNA-Fragmenten, ATP oder Antisense-Oligonucleotiden), die in einem kationischen Mg/Al-Doppelhydroxid intercaliert sind (siehe Bild). Mit einem derartigen Hybridsystem können Wirkstoffe oder auch Gene transportiert und aus dem anorganischen, nicht cytotoxischen Carrier freigesetzt werden. Dies wurde durch Experimente belegt, bei denen sich der Carrier in einer Leukämiezelle unter Abgabe der wachstums
The inorganic layered double hydroxide support, Mg4Al2(OH)12(NO3)2·mH2O, could be obtained by coprecipitation in aqueous solution; the interlayered NO3− anions can be replaced by biomolecules such as cytidine 5′-monophosphate, adenosine 5′-monophosphate, guanosine 5′-monophosphate and adenosine 5′-triphosphate to form new biomolecule–LDH hybrids. Upon intercalating these biomolecules into hydroxide layers, the interlayer distance increases from 8.7 Å (for NO3−) to 14.5 Å, 16.9 Å, 18.4 Å, and 19.
In this feature article, the applications of layered nanomaterials as green materials are demonstrated along with their structures and properties. Due to the unique 2-dimensional structures and biocompatibility, various eco- and bio-friendly materials can be hybridized with layered nanoparticles such as layered double hydroxides (LDHs), hydroxy double salts (HDSs) and cationic clays. From small molecules such as drugs, herbicides, fertilizers, and food ingredients to large substances like deoxyr
Abstract The surface of layered double hydroxide nanoparticles, a potential drug‐delivery nanovehicle, is modified with the cancer‐cell‐specific ligand, folic acid. The surface modification is successfully accomplished through step‐by‐step coupling reactions with aminopropyltriethoxysilane and 1‐ethyl‐3‐(3‐dimethyl aminopropyl)‐carbodiimide. In order to evaluate the cancer‐cell targeting effect of folic‐acid‐grafted layered double hydroxide utilizing fluorescence‐related assay, both layered doub
The free modulation of interlayer distance in a layered high-transition temperature (high-Tc) superconductor is of crucial importance not only for the study of the superconducting mechanism but also for the practical application of high-Tc superconducting materials. Two-dimensional (2D) superconductors were achieved by intercalating a long-chain organic compound into bismuth-based high-Tc cuprates. Although the intercalation of the organic chain increased the interlayer distance remarkably, to t
A novel chemical exfoliation of perovskite-like KCa2Nb3O10 utilising an amino acid intermediate is described. At first, amino acid intercalated layered perovskite is prepared by ion-exchange reaction between the interlayer protons in HCa2Nb3O10 and cationic aminoundecanoic acid (H3N+(CH2)10COOH; AUA) under an acidic aqueous solution (pH ca. 3). Upon intercalation, the basal spacing of HCa2Nb3O10 expands from 14.7 Å to 30.4 Å to form a paraffin-like monolayer arrangement of interlayered AUA molec
The biodegradable inorganic nanovector based on a layered double hydroxide (LDH) holds great promise for gene and drug delivery systems. However, in vivo targeted delivery of genes through LDH still remains a key challenge in the development of RNA interference therapeutics. Here, we describe in vivo and in vitro delivery system for Survivin siRNA (siSurvivin) assembled with passive LDH with a particle size of 100 nm or active LDH conjugated with a cancer overexpressing receptor targeting ligand
