Jinyoung Youn
성균관대학교 의예과 · 의학
이 교수의 연구실은 파킨슨병의 임상적 특성과 생물학적 기전을 이해하기 위해 웨어러블 기반의 자동 상태 감지 기술과 생체막대체 물질을 활용한 진단 생물학적 마커 탐색에 중점을 두고 있습니다. 특히 약물 투여 상태(On/Off 상태)의 실시간 모니터링과 자율호흡 관련 단백질의 변화를 통해 조기 진단 및 병행 관리 전략을 개발하고 있습니다. 또한, 파킨슨병 환자에서의 낙상 원인과 인지 수준에 대한 사회적 인지 연구를 병행하여 종합적인 환자 관리 모델을 구축하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Fluctuations in motor symptoms are mostly observed in Parkinson's disease (PD) patients. This characteristic is inevitable, and can affect the quality of life of the patients. However, it is difficult to collect precise data on the fluctuation characteristics using self-reported data from PD patients. Therefore, it is necessary to develop a suitable technology that can detect the medication state, also termed the "On"/"Off" state, automatically using wearable devices; at the same time, this coul
The roles of autophagy-related proteins as diagnostic or monitoring biomarkers in Parkinson's disease (PD) have not been clearly elucidated. We recruited 32 patients with early-stage PD and 28 control subjects, and evaluated parkinsonian motor symptoms and dopamine transporter imaging data. Cerebrospinal fluid (CSF) levels of LC3B, Beclin1, and LAMP-2 were estimated using ELISAs, and CSF levels of ATG5, ATG7, and p62 were examined by immunoblotting. Additionally, we also assessed the levels of α
Falls are a common and disabling symptom in patients with Parkinson's disease (PD). For prevention, it is important to understand the pathophysiology of falls in PD patients, but the predictors for the possible mechanisms underlying such falls have not been clearly elucidated. In this prospective observational study, we investigated the implications of falling direction to predict the mechanisms of recurrent falls in PD patients. We enrolled 62 recurrent fallers with PD and divided them into two
Awareness and knowledge of PD showed hierarchical gradients with respect to age, income and education level. Pertinent educational strategies and approaches targeting specific subgroups are necessary to improve public awareness and knowledge about PD.
