Nagoya University · 공학
지로 카사하라 교수의 연구실은 신경세포 내 칼슘 신호 전달 메커니즘을 중심으로, 특히 CaMKII와 CaMKIV를 포함한 칼슘/모듈린 의존성 단백질 키나제의 조절 메커니즘과 그 기능을 규명하는 데 초점을 맞추고 있습니다. 주로 해마의 장기 강화(LTP)와 관련된 신호 전달 경로에서 CaMKIV가 CREB를 인산화하여 학습 및 기억 형성에 기여하는 메커니즘을 연구하고 있으며, 단백질 인산화/탈인산화 조절에 관여하는 효소들(예: PP1, PP2A, 계산백)의 기여를 분석하고 있습니다. 이는 신경 생물학 및 뇌 기능의 분자 기전 이해에 기여합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The importance of well characterized calcium/calmodulin-dependent protein kinase (CaMK) II in hippocampal long term potentiation (LTP) is widely well established; however, several CaMKs other than CaMKII are not yet clearly characterized and understood. Here we report the activation of CaMKIV, which is phosphorylated by CaMK kinase and localized predominantly in neuronal nuclei, and its functional role as a cyclic AMP-responsive element-binding protein (CREB) kinase in high frequency stimulation
journal article
journal article
How to generate a steady-state detonation around a hypersonic projectile in stoichiometric hydrogen-oxygen premixed gases is studied. The speed of the hypersonic projectiles was beyond the Chapman ‐Jouguet(C‐J) detonation speed. The e owe eld around the projectile was visualized by using a gate intensie ed charge-coupled device camera(single-frame schlieren picturesand OHradical self-emissionimages ). Threeparameters are varied:1 ) the projectile e ight length from diaphragm rupture location, 2
Calcium/calmodulin-dependent protein kinases (CaM kinases) are major multifunctional enzymes that play important roles in calcium-mediated signal transduction. To characterize their regulatory mechanisms in neurons, we compared glutamate-induced phosphorylation of CaM kinase IV and CaM kinase II in cultured rat hippocampal neurons. We observed that dephosphorylation of these kinases followed different time courses, suggesting different regulatory mechanisms for each kinase. Okadaic acid, an inhi
