이화여자대학교 · 의학
이 연구실은 B세포의 발달 과정에서 발견된 새로운 전구성 난세포(Pre-naive B cell)의 생물학적 특성과 기능을 규명하며 면역학적 기전을 탐구하고 있습니다. 동시에 식물성 항산화 물질인 월넛 추출물이 결장암 세포의 간선세포(성분세포)에 미치는 영향을 분석하여 암 치료의 새로운 전략을 모색하고 있습니다. 특히 자궁경부암 등 여성의 자궁경비기 동안 높은 위험을 보이는 자가면역질환, 예를 들어 레이노병증의 메커니즘에 대한 연구도 진행 중입니다. 이는 여성의 건강을 고려한 맞춤형 의학적 접근을 추구하는 데 초점이 맞춰져 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
We have identified a distinct pre-naive B cell population circulating in human peripheral blood that exhibits an intermediate phenotype between transitional and naive B cells. Like human transitional B cells, these cells express CD5 but have intermediate densities of CD38, CD10, CD9, and the ABCB1 transporter compared with transitional and naive B cells. These pre-naive B cells account for a majority of circulating human CD5(+) B cells. Importantly, CD5(+) pre-naive B cells could be induced to d
Walnut has been known for its health benefits, including anti-cardiovascular disease and anti-oxidative properties. However, there is limited evidence elucidating its effects on cancer stem cells (CSCs) which represent a small subset of cancer cells that provide resistance against chemotherapy. This study aimed to evaluate the anti-CSCs potential of walnut phenolic extract (WPE) and its bioactive compounds, including (+)-catechin, chlorogenic acid, ellagic acid, and gallic acid. In the present s
The risk and burden of SLE are high among women during their childbearing years. This calls for special attention to this particular population group when allocating health resources.
Sepsis remains a field of active research with many unknown and unanswered questions. Over the past few decades, advancements in sepsis management have led to improved mortality and morbidity. This article will review the current evidence-based practices of the treatment of sepsis and septic shock. It will also critically appraise some of the current controversies in sepsis management, such as fluids, steroids, early vasopressors, early goal-directed therapy and immunotherapy.
This paper reviews the on-going research trends of the ongoing researches conducted in various disciplines on Massive Open Online Course, or MOOC. The background overview on MOOC is organized descriptively and chronologically from the materials collected from the late 2000s to the current days. The paper then focuses on the usage of MOOC as an e-Learning open education platform in the context that it deals with the problems related to the digital divide. MOOC allows many users to participate wit
These data demonstrate that the SLE V(lambda)-J(lambda) repertoire manifests characteristics of normal adult IgM+,CD5+ and fetal B cell populations that are known to be enriched for the production of natural autoantibodies.
Primary Sjogren's syndrome (pSS) is a chronic autoimmune disease with well-documented association of lymphoid malignancies during the progress of the disease. Although several types of malignancy and pseudomalignancy have been reported in pSS, low-grade non-Hodgkin's lymphomas are the most frequently observed. Reactive plasmacytosis mimicking myeloma is a very rare condition in association with pSS. We describe a 72-yr-old woman with pSS who presented with hypergammaglobulinemia, and extensive b
B cells play an essential role in humoral immunity by producing antigen-specific antibodies. However, B cells also participate in cellular immune responses by presenting antigens, providing costimulation, and producing cytokines to activate and expand effectors and memory T cell populations. Recent identification of antibody-independent functions of B cells has reawakened interest in the many roles of B cells in normal immune responses as well as in autoimmune diseases. B cells interact with oth
Given the many features we examined, ACEi/ARBs were associated with increased 1-year survival among elderly patients after an AMI. We found LLR to be the best-performing model over RF to predict 1-year survival after an AMI. LLR greatly improved the generalization of the model by feature selection, which implicitly indicates the association between AMI-related variables and survival can be defined by a relatively simple model with a small number of features. Some comorbidities were associated wi
Goal-setting is a valuable behavior change strategy. For patients with multiple sclerosis, a variety of factors such as symptoms (e.g., pain, fatigue), environmental factors (e.g., weather), and mood can all greatly influence a person's ability to meet daily goals. Based on this, these patients and others with chronic pain, would likely benefit from strategies that could aid them in developing their own personalized physical activity goals that can take into account these factors dynamically. Th
While SvMSCs produced fibrous tissue during default <i>in vitro</i> chondrogenesis, their fibrocartilage generation potential in the presence of static tension was significantly lower, compared with MCs. Our results support evaluation of cellular response to tensile stimulus as a decisive factor in determining the ideal cell source for fibrocartilage reconstruction.
These indolent PTCLs histologically show diffuse infiltrated small lymphoid cells with low KI-67 labeling index and have a relatively good prognosis, although the epidemiology and pathogenesis are not fully elucidated. We report a case of indolent PTCL with cytogenetic abnormalities and poor response to chemotherapy, along with a brief review of the literature.
The goal of this project is to develop tools that support users' creation of their own behavior-change plans. We conducted two formative user studies to explore people's creation of plans for their own behavioral goals. Users were provided with minimal support to facilitate goal-setting, use of behavior-change techniques, and self-monitoring. In this paper, we present insights on how to further facilitate personalization of behavior-change plans.
