Jong‐Hwan Lee
고려대학교 의과대학 · 신경과학
이 교수의 연구실은 광학 간섭단층촬영(OCT)과 동적 빛산산란(DLS)을 융합한 고해상도 3차원 생체 이미징 기술을 핵심으로 하며, 뇌혈관 및 미소혈관에서의 적혈구 이동, 혈류 속도, 세포 내 운동 등을 동시에 정량적으로 측정하는(label-free, 실시간) 기술 개발에 주력하고 있습니다. 특히 심장 및 호흡 운동에 의한 영상 왜곡 보정, 다층 혈관에서의 동역학적 유체역학 분석 등 생체 내 복잡한 유체 흐름을 고해상도로 분석하는 데에 기여하고 있습니다. 이는 뇌 기능 진단 및 수술 중 유체 반응성 예측 등 임상적 응용에도 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
We introduce an integration of dynamic light scattering (DLS) and optical coherence tomography (OCT) for high-resolution 3D imaging of heterogeneous diffusion and flow. DLS analyzes fluctuations in light scattered by particles to measure diffusion or flow of the particles, and OCT uses coherence gating to collect light only scattered from a small volume for high-resolution structural imaging. Therefore, the integration of DLS and OCT enables high-resolution 3D imaging of diffusion and flow. We d
In this paper, we proposed new speech features using independent component analysis to human speeches. When independent component analysis is applied to speech signals for efficient encoding the adapted basis functions resemble Gabor-like features. Trained basis functions have some redundancies, so we select some of the basis functions by the reordering method. The basis functions are almost ordered from the low frequency basis vector to the high frequency basis vector. And this is compatible wi
Cardiac and respiratory motions in animals are the primary source of image quality degradation in dynamic imaging studies, especially when using phase-resolved imaging modalities such as spectral-domain optical coherence tomography (SD-OCT), whose phase signal is very sensitive to movements of the sample. This study demonstrates a method with which to compensate for motion artifacts in dynamic SD-OCT imaging of the rodent cerebral cortex. We observed that respiratory and cardiac motions mainly c
As capillaries exhibit heterogeneous and fluctuating dynamics even during baseline, a technique measuring red blood cell (RBC) speed and flux over many capillaries at the same time is needed. Here, we report that optical coherence tomography can capture individual RBC passage simultaneously over many capillaries located at different depths. Further, we demonstrate the ability to quantify RBC speed, flux, and linear density. This technique will provide a means to monitor microvascular flow dynami
PPV could predict fluid responsiveness only during protective OLV, but not conventional OLV. PPV would be helpful for fluid management in patients receiving protective OLV for lung surgery using thoracotomy.
This paper describes a novel optical method for label-free quantitative imaging of cerebral blood flow (CBF) and intracellular motility (IM) in the rodent cerebral cortex. This method is based on a technique that integrates dynamic light scattering (DLS) and optical coherence tomography (OCT), named DLS-OCT. The technique measures both the axial and transverse velocities of CBF, whereas conventional Doppler OCT measures only the axial one. In addition, the technique produces a three-dimensional
We present a novel optical coherence tomography (OCT)-based technique for rapid volumetric imaging of red blood cell (RBC) flux in capillary networks. Previously we reported that OCT can capture individual RBC passage within a capillary, where the OCT intensity signal at a voxel fluctuates when an RBC passes the voxel. Based on this finding, we defined a metric of statistical intensity variation (SIV) and validated that the mean SIV is proportional to the RBC flux [RBC/s] through simulations and
