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Vast numbers of studies and developments in the nanotechnology area have been conducted and many nanomaterials have been utilized to detect cancers at early stages. Nanomaterials have unique physical, optical and electrical properties that have proven to be very useful in sensing. Quantum dots, gold nanoparticles, magnetic nanoparticles, carbon nanotubes, gold nanowires and many other materials have been developed over the years, alongside the discovery of a wide range of biomarkers to lower the

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-hydrogen bond activation through a binuclear carbon-hydrogen bond complexJoon Won. Park, Peter B. Mackenzie, William P. Schaefer, and Robert H. GrubbsCite this: J. Am. Chem. Soc. 1986, 108, 20, 6402–6404Publication Date (Print):October 1, 1986Publication History Published online1 May 2002Published inissue 1 October 1986https://doi.org/10.1021/ja00280a054RIGHTS & PERMISSIONSArticle Views296Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Vie

There has been enormous interest in understanding and utilizing plasmon-enhanced fluorescence (PEF) with metal nanostructures, but maximizing the enhancement in a reproducible, quantitative manner while reliably controlling the distance between dyes and metal particle surface for practical applications is highly challenging. Here, we designed and synthesized fluorescence-amplified nanocuboids (FANCs) with highly enhanced and controlled PEF signals, and fluorescent silica shell-coated FANCs (FS-F

The streptavidin–biotin interaction on a monolayer of a conically shaped dendrimer was investigated by surface plasmon resonance (SPR) spectroscopy and the interaction on the mesospaced surface was found to be as efficient as the one on the mixed monolayers at a lower concentration of immobilized biotin.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure and reactivity of a titanocene (.eta.2-thioformaldehyde) trimethylphosphine complexJoon Won Park, Lawrence M. Henling, William P. Schaefer, and Robert H. GrubbsCite this: Organometallics 1990, 9, 5, 1650–1656Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/om00119a042https://doi.org/10.1021/om00119a042research-articleACS PublicationsRequest reuse per

The heteronuclear mu-methylene mu-phenyl complexes Cp2Ti(mu-CH2)[mu-p-(CH3)2NC6H4]Rh(1,5-COD) (3b) (1,5-COD = 1,5-cyclooctadiene) and Cp2Ti(mu-CH2)(mu-o-MeOC6H4)RH((1,5-COD) (3c) were synthesized from Cp2Ti(mu-CH2)(mu-Cl)Rh(1,5-COD) (1) and the appropriate aromatic lithium reagent. The structure of 3b was determined by single-crystal X-ray crystallography. The two metal atoms are bridged by the mu-methylene carbon remaining from 1 and by ipso carbon of the p-(N,N-dimethylamino)phenyl group. Comp

Picoforce atomic force microscopy (AFM) and specific DNA hybridization have been used to lock on to synthetic nano-π-stacks, revealing the secrets of thermophilic, albeit weak, π–π interactions. A cone-shaped dendron created an appropriate lateral spacing to ensure that most times a single stack was confined between the tip and the substrate, eliminating undesired multi-molecular pulling and greatly simplifying data analysis.

Interest in well-defined surface architectures has shown a steady increase, particularly among those involved in biological applications where the reactivity of functional groups on the surface is desired to be close to that of the solution phase. Recent research has demonstrated that utilizing the self-assembly process is an attractive and viable choice for the fabrication of two-dimensional nanoscale-controlled architectures. This review highlights representative examples for controlling the s

Cell-free DNA (cfDNA) analysis, specifically circulating tumor DNA (ctDNA) analysis, provides enormous opportunities for noninvasive early assessment of cancers. To date, PCR-based methods have led this field. However, the limited sensitivity/specificity of PCR-based methods necessitates the search for new methods. Here, we describe a direct approach to detect KRAS G12D mutated genes in clinical ctDNA samples with the utmost LOD and sensitivity/specificity. In this study, MutS protein was immobi