Ju‐Hong Min
성균관대학교 의과대학 · 의학
Ju-Hong Min 교수의 연구실은 신경면역질환, 특히 뇌경색 및 뇌염증성 질환의 병태생리와 뇌 구조-기능 연결을 중심으로 연구를 진행하고 있습니다. 주로 뉴로마이엘로파티 및 뇌경색을 동반한 자가면역성 뇌질환에서의 뇌 영상 소견, 인지기능 저하, 피로와 삶의 질의 상관관계를 분석하며, 특히 수축성 뇌질환에서의 백질 연결성 변화를 그래프 이론을 활용해 규명하고자 합니다. 또한 신경면역질환 치료제의 안전성과 유효성에 대한 임상 연구도 병행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
We report the case of a patient who developed extensive brain lesions during fingolimod (FTY720) treatment in the TRANSFORMS study. His initial diagnosis was multiple sclerosis, but after encephalopathy anti-aquaporin4 antibody (anti-AQP4 Ab) was detected, it was changed to neuromyelitis optica spectrum disorder. After treatment with fingolimod, he developed bilateral extensive brain lesions. The brain MRI showed lesions predominantly involving the right frontal and parietal lobes, with vasogeni
Age of onset could be an important predictor of lesion location and clinical course of patients with NMOSD.
To evaluate the efficacy and safety of ursodeoxycholic acid (UDCA) with oral solubilized formula in amyotrophic lateral sclerosis (ALS) patients, patients with probable or definite ALS were randomized to receive oral solubilized UDCA (3.5 g/140 mL/day) or placebo for 3 months after a run-in period of 1 month and switched to receive the other treatment for 3 months after a wash-out period of 1 month. The primary outcome was the rate of progression, assessed by the Appel ALS rating scale (AALSRS),
Fatigue is a prevalent symptom and major burden in neuroimmunological diseases. In neuromyelitis optica spectrum disorder (NMOSD), a severe autoimmune central nervous system (CNS) inflammatory disease with autoantibodies reactive to aquaporin-4, there are few reports about fatigue and quality of life (QOL). We aimed to evaluate the severity of fatigue and its relationship with QOL in patients with NMOSD. We prospectively studied patients with NMOSD who were in remission and seropositive for anti
<b>Background:</b> In neuromyelitis optica spectrum disorder (NMOSD), brain involvement is common and cognitive dysfunction is frequently found. The study investigated alterations of white matter (WM) connectivity using graph theory and correlations with cognitive dysfunction in patients with NMOSD. <b>Methods:</b> We prospectively enrolled patients with NMOSD (<i>N</i> = 14) and age- and sex-matched healthy controls (<i>N</i> = 21). Structural connections between any pair of the 90 cortical and
The implications for clinical settings and the suggestions for future research are discussed.
The risk of dementia increased in MS and NMOSD patients and dementia risk was higher in MS than in NMOSD.
UA levels are associated with clinical disease status in patients with NMO. Further investigations are recommended to elucidate the role of UA as a biomarker of disease activity in NMO.
Background People with multiple sclerosis (MS) are more likely to develop stroke than those without. However, little is known about the association between neuromyelitis optica spectrum disorder (NMOSD) and the risk of stroke. We aimed to estimate the risk of stroke in patients with MS and NMOSD in South Korea. Methods Data from the Korean National Health Insurance between January 2010 and December 2017 were analysed. A total of 1541/1687 adult patients with MS/NMOSD, who were free of stroke wer
The most common diagnoses with elevated CSF-ADA levels were HM, followed by TBM and VM. Clinicians should carefully consider the differential diagnoses in patients with elevated CSF-ADA levels, especially those in the early stage of meningitis without microbiological evidence for TBM.
