The University of Tokyo · 의학
Jun Fujishiro 교수의 연구실은 주로 이식 생존율 향상과 면역 억제 치료의 최적화를 목표로 하며, 특히 KRP-203와 같은 S1P 수용체 조절제의 장기적 효과와 약물 상호작용에 대한 기초 연구를 진행하고 있습니다. 또한 어린이 복잡성 맹장염에서 복강 배액의 임상적 유용성에 대한 다국적 데이터 기반 분석을 통해 수술적 결과 개선 전략을 모색하고 있습니다. 신장 유전자 치료 및 심장질환을 동반한 신생아의 저산소성 호흡기 증후군에 대한 기전 연구를 통해 다양한 임상 분야에 기여하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Background. We demonstrate the long-term effectiveness of KRP-203 treatment in combination with a subtherapeutic dose of cyclosporine A (CsA) on rat renal allografts. Methods. We tested the effect of KRP-203 in combination with CsA using a rat skin allograft model. The Pharmacokinetic interaction between CsA and KRP-203 was evaluated. The selectivity of KRP-203 for sphingosine-1-phosphate (S1P)1 and S1P3 receptors were investigated in vitro. Heart rate alteration following bolus injection of pho
Objective: The aim of the study was to investigate the effect of abdominal drainage at appendectomy for complicated appendicitis in children. Summary of Background Data: Although an abdominal drain placement at appendectomy is an option for reducing or preventing postoperative infectious complication, there is controversy regarding its effect for complicated appendicitis. Method: The study used the data on appendectomies for complicated appendicitis in children (≤15 years old) that were operated
This study suggested that an abdominal drain placement at appendectomy for complicated appendicitis among children has no advantage and can be harmful for preventing postoperative complications.
This study generated new information about in vivo and ex vivo gene transfer into the kidney, which would be useful for renal gene therapy.
While D-HB was frequently observed in infants with CHD, the majority of D-HB cases resolved spontaneously in ≤1 week. Neonatal clinical parameters or CHD status was not predictive of D-HB. D-HB lasting >1 week in infants with CHD should be evaluated for the cause.
We examined the effects of two noradrenergic tricyclic antidepressants and two selective serotonin re-uptake inhibitors in the tail suspension test, with a suspension period of 30 min instead of the usual 10 min. Within the first 10 min, desipramine, nortriptyline and fluvoxamine significantly reduced the duration of immobility. Whereas desipramine and nortriptyline were also efficacious in the rest of the test period, fluvoxamine was not. Fluoxetine showed no significant effect throughout the s
