June‐Won Cheong
연세대학교 의과대학 · 의학
June-Won Cheong 교수의 연구실은 급성 백혈병, 특히 급성 골수성 백혈병(AML)의 분자 기전과 치료 전략을 중심으로 연구를 진행하고 있습니다. PTEN 및 Akt 신호전달 경로의 조절, MDSC 유사 백혈병 세포가 유도하는 면역 회피 메커니즘, 그리고 CK2/PI3K/Akt 경로 억제를 통한 백혈병 줄기세포(LSCs) 타겟팅 전략 등, 백혈병의 발병 기전과 약물 내성 극복을 위한 신약 개발에 초점을 맞추고 있습니다. 또한 철 과잉 상태에서의 철 제거 치료(디플라세티드)의 유효성에 대해서도 임상적 적용 가능성을 탐색하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Phosphorylation of PTEN (phosphatase and tensin homologue) affects PTEN protein stability and function. In this study, phosphorylated PTEN (pPTEN) was observed in 45 (73.8%) of 61 cases with acute myeloid leukaemia (AML). Phosphorylation of Akt and its downstream molecules [FKHR; Forkhead (Drosophila) homologue 1; and GSK-3beta; glycogen synthase kinase 3 beta] was significantly associated with pPTEN (P < 0.001). The complete remission rates were not different with respect to pPTEN, but overall
These results indicate that apicidin effectively induces the apoptosis of Bcr-Abl-positive leukemia cells through the activation of the mitochondrial pathway-dependent caspase cascades. The down-regulation of Bcr-Abl mRNA might also be one of the mechanisms implicated in the apicidin-mediated apoptosis in the K562 cells. This study provides the rationale to additionally investigate apicidin as a potential therapeutic agent for the drug-resistant Bcr-Abl-positive leukemia cells.
This study shows that DFX is effective in reducing S-ferritin and LIC level in transfusional iron overload patients with MDS or AA and is well tolerated. In addition, positive effects in hematologic and hepatic function can be expected with DFX. Iron chelation treatment should be considered in transfused patients with MDS and AA when transfusion-related iron overload is documented.
Inhibition of both CK2 and PI3K/Akt pathways may be a promising LSCs-targeted therapeutic strategy for AML.
ISRCTN61498391.
Autophagy is a lysosomal degradation mechanism that is essential for cell survival, differentiation, development, and homeostasis. Autophagy protects cells from various stresses, including protecting normal cells from harmful metabolic conditions, and cancer cells from chemotherapeutics. In the current study, a cytarabine arabinoside (Ara‑C)‑sensitive U937 leukemia cell line and an Ara‑C‑resistant U937 (U937/AR) cell line were assessed for baseline autophagy activity by investigating the LC3‑I c
<b>Background</b>: Unlike therapy-related myeloid neoplasms, therapy-related acute lymphoblastic leukaemia (tr-ALL) is poorly defined due to its rarity. However, increasing reports have demonstrated that tr-ALL is a distinct entity with adverse genetic features and clinical outcomes. <b>Methods:</b> We compared the clinicopathological characteristics and outcomes of patients diagnosed with tr-ALL (<i>n</i> = 9) or <i>de novo</i> ALL (dn-ALL; <i>n</i> = 162) at a single institution from January 2
Hodgkin's disease (HD) is a hematologic malignancy which shows common features regardless of race, but racial differences may be considered with certain clinical characteristics. HD in Korea shows somewhat different characteristics when compared to cases in Western countries. We evaluated the clinical and histopathologic characteristics of HD, the outcomes of various chemotherapy regimens, and prognostic factors of HD in Korea. One hundred and five patients with initial histopathologic diagnosis
Purpose: To compare the efficacy of posterior sub-Tenon’s capsule triamcinolone acetonide injection combined with modified grid macular photocoagulation (PSTI+MP) with intravitreal triamcinolone acetonide (IVTA) injection in the treatment of diffuse diabetic macular edema (DME). Materials and Methods: Forty eyes of 33 patients with diffuse DME were randomly allocated into either PSTI+MP (20 eyes) or IVTA (20 eyes). Best corrected visual acuity (VA) and foveal thickness were measured. Results: Th
Abstract Abstract 2843 Introduction The hypomethylating agents (HMAs) 5-azacitidine (AZA) and decitabine (DAC) provided significant overall response rates (40–60%) in myelodysplastic syndrome (MDS), and improved the outcome of higher risk MDS. However, phase III trials comparing AZA or DAC to conventional treatment including best supportive care have shown discrepant results. The aim of this study is to compare the efficacy and safety between AZA and DAC in patients with MDS. Methods We evaluate
목적 : 한국인의 병적 근시와 동반된 맥락막 신생혈관에서 verteporfin을 이용한 광역학 치료의 효과를 알아보고자 하였다. 대상과 방법 : 맥락막 신생혈관이 발생한 병적 근시 환자 중 광역학 치료를 받고 6개월 이상 추적 관찰이 가능하였던 39명 42안을 대상으로 의무기록을 후향적으로 분석하였으며 시술 전후 시력, 형광 안저 촬영 소견을 비교분석하였다. 결과 : 대상 환자들의 평균 연령은 39.6세였으며, 평균 추적 관찰 기간은 23.5개월이었다. 시력 변화는 시술 후 42안 중 호전 22안(55.4%), 유지 13안(30.9%), 악화 7안(16.7%)으로 나타났다. 형광 안저 촬영상 25안(59.5%)에서 형광 누출의 감소가 관찰 되었다. 결론 : 병적 근시와 동반된 맥락막 신생혈관에서 verteporfin을 이용한 광역학 치료는 한국인에 있어서도 병변의 안정화 및 시력 호전에 효과가 있으며 이러한 효과는 6개월 이상 지속되는 것으로 나타났다.
