Junsik Park
연세대학교 의과대학 내과학교실 · 의학
Junsik Park 교수의 연구실은 난소암을 중심으로 한 고급 암 생물학과 면역치료 전략을 연구하고 있습니다. 특히, PD-1 억제제와 베바시주맙을 포함한 신규 치료법의 임상적 효과와 기전을 규명하며, BRCA1/2 유전자 변이 상태에 따른 면역세포 반응의 이질성을 밝혀내고 있습니다. 또한, 난소암 환자의 생존율 향상을 위한 표적치료 및 면역치료의 융합 전략 개발에 주력하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
South Korea’s social distancing policies on public transportation only involve mandatory wearing of masks and prohibition of food intake, similar to policies on other indoor spaces. This is not because public transportation is safe from coronavirus disease 2019 (COVID-19), but because no suitable policies based on accurate data have been implemented. To relieve fears regarding contracting COVID-19 infection through public transportation, the government should provide accurate information and tak
ClinicalTrials.gov Identifier: NCT04734665.
NCT03899610.
See "Early experiences with PD-1 inhibitor treatment of platinum resistant epithelial ovarian cancer" in volume 30, e56.
Bevacizumab-containing NAC might be safe and provide longer PFS than chemotherapy alone in patients with advanced ovarian cancer. However, further study is necessary to investigate the impact of bevacizumab-containing NAC on OS.
In gynecology, endosalpingiosis is a benign condition in which the fallopian tube-like epithelium is found outside the fallopian tube. The thirty-four point five percent of endosalpingiosis cases have concurrent endometriosis and 40% of the endosalpingiosis group are in postmenopausal states. In contrast with endometriosis, there are no significant links between infertility, chronic pelvic pain and endosalpingiosis. The symptoms of endosalpingiosis are not yet settled. Endosalpingiosis is almost
Our results highlight unique immune features of CD8<sup>+</sup> TILs in EOC and a differential response to anti-PD-1 treatment, contingent on <i>BRCA1/2</i> mutation status. These findings suggest that immune checkpoint blockade may be a promising frontline therapeutic option for selected <i>BRCA1/2</i>wt EOC patients.
Allogenic peripheral blood stem cell transplantation (Allo-PBSCT) is being used to treat hematological malignancies with increasing frequency. Graft-versus-host disease (GvHD) is a complex complication of PBSCT. A 43-year-old woman came to the gynecology clinic for amenorrhea. She had been diagnosed with acute myeloid leukemia 2 years earlier and treated with induction and consolidation chemotherapy. After developing complete remission, she underwent Allo-PBSCT. When she started chemotherapy, he
Abstract Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults and is manifested with poor prognosis. GBM has long been recognized as an immunosuppressive neoplasm characterized by activation of various immune escape mechanisms. Recently, immune checkpoint inhibitors have shown clinically relevant improvements with high response rates and durable tumor remissions in several cancer types, and anti-PD-1, PD-L1 and CTLA-4 blockade are currently tested in clinical trials for
