Tokyo Institute of Technology · 물리·천문학
K. Nakajima 교수의 연구실은 나노스케일에서의 고분성질 분석을 핵심으로 하며, 원자력현미경(AFM)을 활용한 소재의 기계적·점탄성 특성 측정 기술 개발에 주력하고 있습니다. 특히 연성 고분자 및 고분자 혼합막에서의 점탄성 거동을 정량적으로 분석하기 위한 나노팔라션스기반 기계적 성질 지도화 기법을 개발하고 있으며, 이는 생체소재 및 나노소재의 물성 평가에 응용됩니다. 또한, 의료용 생체마커로의 응용 가능성도 탐색하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
We review nano-palpation atomic force microscopy, which offers quantitative mechanical property mapping especially for soft materials. The method measures force-deformation curves on the surfaces of soft materials. The emphasis is placed on how both Hertzian and Derjaguin-Muller-Toporov contact mechanics fail to reproduce the experimental curves and, alternatively, how the Johnson-Kendall-Roberts model does. We also describe the force-volume technique for obtaining a two-dimensional map of mecha
The goal of this study was to investigate Cystatin SN, a cysteine protease inhibitor, as a novel tumor marker for colorectal cancer (CRC). Gene expression profiles of mRNA from normal tissues and cancer cell lines were performed. Twenty-eight monoclonal antibodies for Cystatin SN were generated and serum Cystatin SN was quantified using ELISA in sera from 159 patients with CRC and 40 healthy controls. Cystatin SN was highly expressed in colon cancer cells. Employing a receiver-operating characte
We measured force–distance curves of polystyrene (PS)/poly (vinyl methyl ether) (PVME) blend thin films using atomic force microscopy (AFM) in order to pursue the possible usage of AFM as a tool for detecting viscoelastic properties of polymeric materials from a nanoscopic point of view. In quasi-static measurements of force–distance curves for a sample whose PS content equals 100%, both adhesive force and capillary force were measured separately. A phenomenon possibly assigned to pulling off of
