Hokkaido University · 의학
Kaoruko Shimizu 교수의 연구실은 만성 호흡기질환, 특히 천식과 만성 폐쇄성 폐질환(COPD)의 병태생리학적 기전과 진단·치료 전략을 탐구하고 있습니다. 주요 연구 방향은 폐기능 저하와 기도 리모델링을 조절하는 약물(예: DHMEQ)의 작용 기전, 영상 기반 심층학습을 활용한 GOLD 분류 정확도 향상, 그리고 폐혈관 및 기도 폭발 변화와 관련된 비침습적 생체지표 개발입니다. 특히 기도 염증 프ofile과 흡연 상태에 따른 기침 및 폐기능 변화의 상관관계 분석을 통해 개인 맞춤형 폐질환 관리 전략을 모색하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
These results indicate that DHMEQ inhibits allergic airway inflammation and airway remodelling in murine models of asthma. DHMEQ may have therapeutic potential in the treatment of asthma.
These well-established cohorts clarify the different prognostic roles of %LAV and <i>D</i>, whereby lower <i>D</i> is associated with a higher risk of exacerbation and higher %LAV is associated with a rapid decline in lung function and long-term mortality. Combination of %LAV and fractal <i>D</i> may identify COPD subgroups at high risk of a poor clinical outcome more sensitively.
Recently, deep learning applications in medical imaging have been widely applied. However, whether it is sufficient to simply input the entire image or whether it is necessary to preprocess the setting of the supervised image has not been sufficiently studied. This study aimed to create a classifier trained with and without preprocessing for the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification using CT images and to evaluate the classification accuracy of the GOLD cla
The overlap between asthma and chronic obstructive pulmonary disease (COPD) has attracted the interest of pulmonary physicians; thus, measurement of carbon monoxide diffusion capacity (DLco) and/or transfer coefficients (Kco, DLco/V<sub>A</sub>) may become valuable in clinical settings. How these parameters behave in chronic obstructive lung diseases is poorly understood. We predicted that Kco might more accurately reflect emphysematous changes in the lungs than DLco. We examined DLco and Kco in
PA/Ao, %CSA<sub><5</sub>, and PVD are useful non-invasive pulmonary vasculature metrics, both alone and in combination, for diagnosis and haemodynamic assessment of PAH.
The association of mucus plug score with exacerbation frequency and reduced lung function may vary due to airway inflammatory profile and smoking status in asthma.
