Nagoya University · 물리·천문학
Katsunori Yogo 교수의 연구실은 주로 촉매 및 방사선 생물학 분야에서 활동하며, 질소산화물(NO)의 선택적 환원을 위한 고성능 제올라이트 기반 촉매 개발과 함께, 금 나노입자(AuNPs)를 활용한 방사선 감도 향상 메커니즘을 규명하고자 합니다. 특히, 저농도의 양전하 금 나노입자를 이용한 DNA 손상 및 활성산소종(ROS) 생성에 대한 영향을 분석하며, 방사선 치료의 정밀성과 효능을 높이기 위한 기초 연구를 진행하고 있습니다. 또한, 임상 방사선 치료의 정밀한 품질 보증을 위한 실시간 촉광 측정 기술 개발도 함께 진행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Abstract Selective reduction of nitric oxide with methane or ethane in the presence of excess oxygen was investigated using a gallium ion-exchanged ZSM-5 zeolite catalyst(Ga-ZSM-5). Ga-ZSM-5 was highly active and selective for NO reduction above 400 °C. The limiting molar ratios of reacted NO to consumed carbon in C2H6 and CH4 at 500 °C were found to be 1.5 and 2, respectively.
Abstract The reduction of NO with propane in the presence of excess oxygen was investigated using gallium ion-exchanged zeolite catalysts, among which ferrierite(Ga-ferrierite) and ZSM-5(Ga-ZSM-5) showed high activity in a wide range of reaction temperature.
Type-II DNA topoisomerases resolve DNA entanglements such as supercoils, knots and catenanes by passing one segment of DNA duplex through a transient enzyme-bridged double-stranded break in another segment. The ATP-dependent passage reaction has previously been demonstrated at the single-molecule level, showing apparent processivity at saturating ATP. Here we directly observed the strand passage by human topoisomerase IIα, after winding a pair of fluorescently stained DNA molecules with optical
Quality assurance (QA) of clinical electron beams is essential for performing accurate and safe radiation therapy. However, with advances in radiation therapy, QA has become increasingly labor-intensive and time-consuming. In this paper, we propose a tissue-equivalent plastic scintillator for quick and easy QA of clinical electron beams. The proposed tool comprises a plastic scintillator plate and a charge-coupled device camera that enable the scintillation light by electron beams to be recorded
+AuNPs at low concentrations displayed stronger radiosensitization compared to -AuNPs. Combining +AuNPs with 192Ir γ-rays in HDR brachytherapy is a candidate method for improving clinical outcomes. Future development of cancer cell-specific +AuNPs would allow their wider application for HDR brachytherapy.
Gold nanoparticles (AuNPs) can be used with megavolt (MV) X-rays to exert radiosensitization effects, as demonstrated in cell survival assays and mouse experiments. However, the detailed mechanisms are not clear; besides physical dose enhancement, several chemical and biological processes have been proposed. Reducing the AuNP concentration while achieving sufficient enhancement is necessary for the clinical application of AuNPs. Here, we used positively charged (+) AuNPs to determine the radiose
With advances in high-dose-rate (HDR) brachytherapy, the importance of quality assurance (QA) is increasing to ensure safe delivery of the treatment by measuring dose distribution and positioning the source with much closer intervals for highly active sources. However, conventional QA is time-consuming, involving the use of several different measurement tools. Here, we developed simple QA method for HDR brachytherapy based on the imaging of Cherenkov emission and evaluated its performance. Light
The accurate measurement of the 3D dose distribution of carbon-ion beams is essential for safe carbon-ion therapy. Although ionization chambers scanned in a water tank or air are conventionally used for this purpose, these measurement methods are time-consuming. We thus developed a rapid 3D dose-measurement tool that employs a silver-activated zinc sulfide (ZnS) scintillator with lower linear energy transfer (LET) dependence than gadolinium-based (Gd) scintillators; this tool enables the measure