東京大学 · Medicine
이 교수의 연구실은 노화와 관련된 건강 문제, 특히 구강 건강과 근육량 감소(근육쇠약)의 상관관계를 중심으로 노화 예방과 건강한 노화를 위한 종합적 접근을 연구하고 있습니다. 특히 구강 프리플레리티, 근육쇠약, 대사 증후군 등 노인 건강의 핵심 요소들을 기반으로 조기 진단 및 예방 전략을 개발하고 있으며, 환경와 지역사회 기반의 지원 체계 구축을 위한 정책 제안도 함께 진행하고 있습니다. 연구는 임상적 데이터 분석과 분자 생물학적 메커니즘 규명을 병행하여, 개인에서 사회적 차원까지 영향을 미치는 종합적 연구를 추구합니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Accumulated poor oral status strongly predicted the onset of adverse health outcomes, including mortality among the community-dwelling elderly. Prevention of oral frailty at an earlier stage is essential for healthy aging.
The presence of sarcopenia could be detected using three easily obtainable variables with high accuracy. The screening test we developed could help identify functionally independent older adults with sarcopenia who are good candidates for intervention.
These results suggest that the downregulation of cyclin A gene expression may contribute to the antiproliferative effect of red wine polyphenols on RASMCs through the inhibition of transcription factor expression.
RWPs inhibit the SMC migration through the inhibition of 2 distinct signaling pathways and thus exert antiatherogenic actions.
In this report, we have put together a vision for the future of an aging Japanese society from a broader perspective of how the environment and local communities should be, rather than simply from the perspective of individual health. We aim to convey this proposal to the Ministry of Health, Labor and Welfare, the Ministry of Education, Culture, Sports, Science and Technology, the Cabinet Office, and various professional organizations. The paradigm shift from "cure-seeking medical care" to "cure
Recent epidemiological evidence suggests that effects of cardiovascular risk factors may vary depending on sex and age. In this study, we assessed the associations of metabolic syndrome (MetS) with sarcopenia and its components in older adults, and examined whether the associations vary by sex and age. We also tested if any one of the MetS components could explain the associations. We conducted a cross-sectional analysis of the baseline data from the cohort study conducted in Kashiwa city, Chiba
The effects of sarcopenic obesity, the co-existence of sarcopenia and obesity, on mood disorders have not been studies extensively. Our objective was to examine the association of depressive symptoms with sarcopenia and obesity status in older Japanese adults. We analyzed data from 1731 functionally-independent, community-dwelling Japanese adults aged 65 years or older (875 men, 856 women) randomly selected from the resident register of Kashiwa city, Chiba, Japan in 2012. Sarcopenia was defined
The OF-5 showed strong predictive validity for physical frailty, physical disability and mortality in Japanese older adults. This assessment tool can be implemented in various settings and foster comprehensive prevention through interprofessional collaboration. Geriatr Gerontol Int 2023; 23: 651-659.
The "Yubi-wakka" test is an extremely practical method to identify older adults at risk of sarcopenia, disability and mortality. This test might contribute to increased primary prevention for sarcopenia by serving as an early wake-up call for older adults against becoming sarcopenic. Geriatr Gerontol Int 2018; 18: 224-232.
The study findings suggest that oral frailty could predict the risk of new-onset MCI in community-dwelling older adults. Further, we found that oral frailty with physical frailty exacerbated this risk, implying the existence of direct or additive effects on cognitive dysfunction. Comprehensive oral health focusing on maintaining eating function can be a strategy to prevent MCI and delay dementia in community-dwelling older adults.
